HCSGD entry for MCM6
1. General information
| Official gene symbol | MCM6 |
|---|---|
| Entrez ID | 4175 |
| Gene full name | minichromosome maintenance complex component 6 |
| Other gene symbols | MCG40308 Mis5 P105MCM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003697 | Single-stranded DNA binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0006260 | DNA replication | NAS TAS | biological_process |
| GO:0006268 | DNA unwinding involved in DNA replication | IEA | biological_process |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0042555 | MCM complex | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9741056305 | 0.0001159264 | 0.9999902473 | 0.0193120253 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4144375782 |
| GSE13712_SHEAR | Down | -0.2327517750 |
| GSE13712_STATIC | Down | -0.0395689202 |
| GSE19018 | Down | -1.0241888475 |
| GSE19899_A1 | Down | -1.3768925704 |
| GSE19899_A2 | Down | -1.9578389294 |
| PubMed_21979375_A1 | Down | -3.0570228519 |
| PubMed_21979375_A2 | Down | -2.1616605530 |
| GSE35957 | Down | -0.9630421162 |
| GSE36640 | Down | -3.7387826012 |
| GSE54402 | Down | -1.1797179342 |
| GSE9593 | Down | -0.7290936729 |
| GSE43922 | Down | -1.8905987373 |
| GSE24585 | Up | 0.1537018168 |
| GSE37065 | Down | -0.5110122127 |
| GSE28863_A1 | Up | 0.4298349406 |
| GSE28863_A2 | Up | 0.9924581190 |
| GSE28863_A3 | Down | -0.2531143429 |
| GSE28863_A4 | Down | -0.1701201826 |
| GSE48662 | Down | -1.1132461557 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016611 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016611 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-1 | MIMAT0000416 | MIRT024027 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024879 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025545 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026808 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-1180-3p | MIMAT0005825 | MIRT035931 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
