HCSGD entry for MCL1
1. General information
| Official gene symbol | MCL1 |
|---|---|
| Entrez ID | 4170 |
| Gene full name | myeloid cell leukemia sequence 1 (BCL2-related) |
| Other gene symbols | BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001709 | Cell fate determination | NAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | IBA TAS | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0005829 | Cytosol | ISS | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IBA | biological_process |
| GO:0008637 | Apoptotic mitochondrial changes | IEA | biological_process |
| GO:0015031 | Protein transport | TAS | biological_process |
| GO:0015266 | Protein channel activity | TAS | molecular_function |
| GO:0016020 | Membrane | IDA ISS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019725 | Cellular homeostasis | NAS | biological_process |
| GO:0034097 | Response to cytokine | IDA | biological_process |
| GO:0042803 | Protein homodimerization activity | IBA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IPI | molecular_function |
| GO:0051434 | BH3 domain binding | IPI | molecular_function |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0071806 | Protein transmembrane transport | TAS | biological_process |
| GO:0097136 | Bcl-2 family protein complex | IDA | cellular_component |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IMP | biological_process |
| GO:0097194 | Execution phase of apoptosis | IDA | biological_process |
| GO:1900118 | Negative regulation of execution phase of apoptosis | TAS | biological_process |
| GO:2000811 | Negative regulation of anoikis | IMP | biological_process |
| GO:2001020 | Regulation of response to DNA damage stimulus | IMP | biological_process |
| GO:2001240 | Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | IMP | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0031835189 | 0.9758131340 | 0.1518248188 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4389924042 |
| GSE13712_SHEAR | Up | 0.2870662058 |
| GSE13712_STATIC | Up | 0.3189201426 |
| GSE19018 | Down | -0.7126740225 |
| GSE19899_A1 | Up | 1.5365858515 |
| GSE19899_A2 | Up | 1.0165756783 |
| PubMed_21979375_A1 | Up | 1.4586671428 |
| PubMed_21979375_A2 | Up | 0.7325923288 |
| GSE35957 | Up | 0.5166865850 |
| GSE36640 | Up | 0.0197642967 |
| GSE54402 | Up | 0.9104788067 |
| GSE9593 | Up | 0.0907756665 |
| GSE43922 | Up | 1.0299558573 |
| GSE24585 | Up | 0.0372009874 |
| GSE37065 | Up | 0.4095404295 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.2420585322 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000877 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000878 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT002485 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 18381414 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT002485 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT002485 | Immunofluorescence//Luciferase reporter assay//Western blot//qRT-PCR | Functional MTI | 23546867 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003286 | qRT-PCR//Western blot | Functional MTI | 19850741 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003286 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20041405 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003286 | Immunohistochemistry//Microarray//Western blot | Functional MTI | 20643754 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT003287 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19850741 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT003287 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 17404574 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT003287 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20041405 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT003287 | Immunohistochemistry//Microarray//Western blot | Functional MTI | 20643754 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT003287 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20657750 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT003288 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20041405 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT003288 | Immunohistochemistry//Microarray//Western blot | Functional MTI | 20643754 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT003288 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-133b | MIMAT0000770 | MIRT003260 | Western blot//Luciferase reporter assay | Functional MTI | 19654003 |
| hsa-miR-133b | MIMAT0000770 | MIRT003260 | Luciferase reporter assay//Western blot | Functional MTI | 20056941 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT003921 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 19155302 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT003921 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT003921 | qRT-PCR | Functional MTI (Weak) | 20712078 |
| hsa-miR-153-3p | MIMAT0000439 | MIRT004080 | Luciferase reporter assay//Western blot//Reporter assay;Other | Functional MTI | 19676043 |
| hsa-miR-153-3p | MIMAT0000439 | MIRT004080 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-512-5p | MIMAT0002822 | MIRT004406 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19503096 |
| hsa-miR-320a | MIMAT0000510 | MIRT004440 | Luciferase reporter assay | Functional MTI | 19096009 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT004663 | Luciferase reporter assay//Western blot | Functional MTI | 20103677 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT004663 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-518a-5p | MIMAT0005457 | MIRT004667 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-582-5p | MIMAT0003247 | MIRT004668 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-661 | MIMAT0003324 | MIRT004743 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-876-3p | MIMAT0004925 | MIRT004744 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-892b | MIMAT0004918 | MIRT004745 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-148b-5p | MIMAT0004699 | MIRT004746 | Luciferase reporter assay//Western blot | Functional MTI | 20829195 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT006949 | Luciferase reporter assay | Functional MTI | 22610076 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT006952 | Luciferase reporter assay | Functional MTI | 22610076 |
| hsa-miR-151a-3p | MIMAT0000757 | MIRT019504 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021163 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030090 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040421 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047799 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT052648 | Luciferase reporter assay//Western blot | Functional MTI | 23756231 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT052649 | Western blot | Functional MTI | 23750239 |
| hsa-miR-3679-3p | MIMAT0018105 | MIRT052877 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-29b-3p | MIMAT0000100 | 1 | hsa-miR-29b | {Immunofluorescence}{Western blot} | {overexpression by miRNA precursor transfection}{overexpression by miRNA precursor transfection} | 17404574 | |
| hsa-miR-193a-3p | MIMAT0000459 | NA | hsa-miR-193a-3p | {Western blot} | {overexpression by miRNA precursor transfection} | 18381414 | |
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 | |||
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-101-3p | MIMAT0000099 | 1 | hsa-miR-101 | 19155302 | |||
| hsa-miR-320a | MIMAT0000510 | 2 | hsa-miR-320a | {Western blot} | {overexpression by miRNA precursor transfection} | 19070389 | |
| hsa-miR-320a | MIMAT0000510 | 1 | hsa-miR-320a | {Western blot} | {overexpression by miRNA precursor transfection} | 19070389 | |
| hsa-miR-29a-3p | MIMAT0000086 | NA | hsa-miR-29a | {Western blot} | {overexpression} | 19850741 | |
| hsa-miR-29b-3p | MIMAT0000100 | 1 | hsa-miR-29b | {Western blot} | {overexpression} | 19850741 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26824319 | The mode of the response to parthenolide is bound to the molecular characteristics of melanoma cells, particularly to the basal MITF-M expression level but other cell-autonomous differences such as NF-kappaB activity and MCL-1 level might also contribute |
| 26711051 | N targets Bcl-2, Bcl-xl, and Bcl-w, while T targets Bcl-2, Bcl-xl, and Mcl-1 |
| 26711051 | The combination of Bcl-2, Bcl-xl, and Bcl-w siRNAs was senolytic in HUVECs and IMR90 cells, while combination of Bcl-2, Bcl-xl, and Mcl-1 siRNAs was not |
| 26299965 | ERK-dependent transcriptional upregulation of Mcl1 was, at least in part, responsible for enhanced survival and slippage of cells with mitotic defects |
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