HCSGD entry for MBNL1
1. General information
| Official gene symbol | MBNL1 |
|---|---|
| Entrez ID | 4154 |
| Gene full name | muscleblind-like splicing regulator 1 |
| Other gene symbols | EXP EXP35 EXP40 EXP42 MBNL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000380 | Alternative mRNA splicing, via spliceosome | IEA | biological_process |
| GO:0000381 | Regulation of alternative mRNA splicing, via spliceosome | IEA | biological_process |
| GO:0001701 | In utero embryonic development | ISS | biological_process |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0006376 | MRNA splice site selection | IEA | biological_process |
| GO:0007399 | Nervous system development | ISS | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0008380 | RNA splicing | IDA | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IDA | cellular_component |
| GO:0030326 | Embryonic limb morphogenesis | ISS | biological_process |
| GO:0043484 | Regulation of RNA splicing | IDA | biological_process |
| GO:0045445 | Myoblast differentiation | ISS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9521958512 | 0.0219473690 | 0.9999902473 | 0.2856193086 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5124622539 |
| GSE13712_SHEAR | Up | 0.0960468614 |
| GSE13712_STATIC | Down | -0.1071943396 |
| GSE19018 | Down | -0.6991319635 |
| GSE19899_A1 | Down | -0.3345476513 |
| GSE19899_A2 | Down | -0.6938158374 |
| PubMed_21979375_A1 | Down | -0.5022763899 |
| PubMed_21979375_A2 | Down | -0.3032801419 |
| GSE35957 | Up | 0.1936198282 |
| GSE36640 | Down | -0.0036535678 |
| GSE54402 | Down | -0.0493150708 |
| GSE9593 | Up | 0.1795757811 |
| GSE43922 | Down | -0.2166147699 |
| GSE24585 | Up | 0.0562156180 |
| GSE37065 | Down | -0.1177879367 |
| GSE28863_A1 | Up | 0.4395350063 |
| GSE28863_A2 | Up | 0.2566258008 |
| GSE28863_A3 | Down | -0.9720411880 |
| GSE28863_A4 | Down | -0.1238859647 |
| GSE48662 | Down | -0.3856492263 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005135 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020228 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022379 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030796 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031192 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040632 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046941 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049609 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050835 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 3889515 | Progressive subcultivation of IMR-90 cells results in non-proliferative, heterogeneous cultures which may reflect aging of the diploid line (Hayflick, Exp |
| 6333569 | These senescent cells, however, still retained the ability to initiate DNA synthesis following infection with SV40 as reported previously [Exp |
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