HCSGD entry for MBD1
1. General information
| Official gene symbol | MBD1 |
|---|---|
| Entrez ID | 4152 |
| Gene full name | methyl-CpG binding domain protein 1 |
| Other gene symbols | CXXC3 PCM1 RFT |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000792 | Heterochromatin | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA NAS | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008327 | Methyl-CpG binding | NAS | molecular_function |
| GO:0016363 | Nuclear matrix | IEA ISS | cellular_component |
| GO:0016607 | Nuclear speck | IEA ISS | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0537827590 | 0.9880352874 | 0.5053903640 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1619897661 |
| GSE13712_SHEAR | Up | 0.0743711284 |
| GSE13712_STATIC | Up | 0.1613896767 |
| GSE19018 | Up | 0.0290833141 |
| GSE19899_A1 | Up | 0.0711884774 |
| GSE19899_A2 | Up | 0.4864376993 |
| PubMed_21979375_A1 | Up | 0.4655993899 |
| PubMed_21979375_A2 | Up | 0.4589791803 |
| GSE35957 | Up | 0.2595260548 |
| GSE36640 | Up | 0.1962811710 |
| GSE54402 | Up | 0.2271433114 |
| GSE9593 | Up | 0.3110728158 |
| GSE43922 | Up | 0.5039870414 |
| GSE24585 | Up | 0.0455490663 |
| GSE37065 | Down | -0.0293553541 |
| GSE28863_A1 | Up | 0.2339890342 |
| GSE28863_A2 | Up | 0.2115398957 |
| GSE28863_A3 | Down | -0.0464644948 |
| GSE28863_A4 | Up | 0.0013605534 |
| GSE48662 | Down | -0.0080861893 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-195-5p | MIMAT0000461 | MIRT007219 | Luciferase reporter assay | Functional MTI | 23349673 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040325 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047606 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-25-3p | MIMAT0000081 | MIRT050283 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
