HCSGD entry for DENND6B
1. General information
| Official gene symbol | DENND6B |
|---|---|
| Entrez ID | 414918 |
| Gene full name | DENN/MADD domain containing 6B |
| Other gene symbols | AFI1B FAM116B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0017112 | Rab guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0032313 | Regulation of Rab GTPase activity | IDA | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | IDA | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA | biological_process |
| GO:0055037 | Recycling endosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2446736180 | 0.9605871433 | 0.9327467130 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0513356135 |
| GSE13712_SHEAR | Down | -0.1009417827 |
| GSE13712_STATIC | Down | -0.2054662451 |
| GSE19018 | Up | 0.3079266768 |
| GSE19899_A1 | Down | -0.0440302656 |
| GSE19899_A2 | Up | 0.1368683798 |
| PubMed_21979375_A1 | Up | 0.1144105452 |
| PubMed_21979375_A2 | Up | 0.1309578735 |
| GSE35957 | Down | -0.0987858107 |
| GSE36640 | Up | 0.3053610392 |
| GSE54402 | Up | 0.1036568532 |
| GSE9593 | Up | 0.1609706216 |
| GSE43922 | Up | 0.1336206399 |
| GSE24585 | Up | 0.1445177148 |
| GSE37065 | Down | -0.0693756128 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.7241781005 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018860 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
