HCSGD entry for MATN1
1. General information
| Official gene symbol | MATN1 |
|---|---|
| Entrez ID | 4146 |
| Gene full name | matrilin 1, cartilage matrix protein |
| Other gene symbols | CMP CRTM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003429 | Growth plate cartilage chondrocyte morphogenesis | IEA | biological_process |
| GO:0005201 | Extracellular matrix structural constituent | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0006461 | Protein complex assembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030500 | Regulation of bone mineralization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4793136545 | 0.8764757342 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0986267078 |
| GSE13712_SHEAR | Down | -0.1195192209 |
| GSE13712_STATIC | Down | -0.0818858631 |
| GSE19018 | Up | 0.1843835455 |
| GSE19899_A1 | Up | 0.0948740469 |
| GSE19899_A2 | Up | 0.0854364780 |
| PubMed_21979375_A1 | Up | 0.3012454069 |
| PubMed_21979375_A2 | Down | -0.0951366872 |
| GSE35957 | Up | 0.2250273744 |
| GSE36640 | Down | -0.0607099789 |
| GSE54402 | Down | -0.0234740056 |
| GSE9593 | Down | -0.1073217270 |
| GSE43922 | Up | 0.0914694792 |
| GSE24585 | Up | 0.0922001102 |
| GSE37065 | Down | -0.0528012455 |
| GSE28863_A1 | Up | 0.0429415972 |
| GSE28863_A2 | Up | 0.0990565635 |
| GSE28863_A3 | Up | 0.3224723582 |
| GSE28863_A4 | Up | 0.1992557326 |
| GSE48662 | Down | -0.1358551845 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23624390 | Our results showed that the bone mineral density and subchondral bone volume were reduced in mandibular condyles, articular surfaces were collapsed, the thickness of articular cartilage and cartilage matrix protein abundance were progressively decreased and eventually led to an erosion of articular cartilage of mandibular condyles |
| 8632215 | In contrast, the addition to cytidine monophosphate (CMP) to the culture media did not increase apoptosis, despite the nucleotide being taken up by the fetal small intestine in a similar dose- and time-dependent manner to AMP |
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