HCSGD entry for MAP2

1. General information

Official gene symbolMAP2
Entrez ID4133
Gene full namemicrotubule-associated protein 2
Other gene symbolsMAP2A MAP2B MAP2C
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001578Microtubule bundle formationIEAbiological_process
GO:0002162Dystroglycan bindingIPImolecular_function
GO:0005198Structural molecule activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005874MicrotubuleIEAcellular_component
GO:0005875Microtubule associated complexTAScellular_component
GO:0007409AxonogenesisIEAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0016358Dendrite developmentIEAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIEAbiological_process
GO:0021954Central nervous system neuron developmentIEPbiological_process
GO:0031175Neuron projection developmentIEPbiological_process
GO:0034399Nuclear peripheryIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0048813Dendrite morphogenesisIEPbiological_process
GO:0071310Cellular response to organic substanceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01069595760.92703867630.26261968281.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5487559058
GSE13712_SHEARUp0.0009604019
GSE13712_STATICUp0.2483776466
GSE19018Down-0.3317363222
GSE19899_A1Up0.1986392666
GSE19899_A2Up0.7278650237
PubMed_21979375_A1Up0.5900330161
PubMed_21979375_A2Up1.2070492956
GSE35957Up0.2448729537
GSE36640Up0.4142777235
GSE54402Up1.4432583264
GSE9593Up0.1990859489
GSE43922Up0.0137500677
GSE24585Up0.0363238058
GSE37065Up0.5255013933
GSE28863_A1Up0.0145435894
GSE28863_A2Up0.2493302170
GSE28863_A3Down-0.0006784193
GSE28863_A4Up0.0512218017
GSE48662Down-0.0772586746

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EstramustineDB01196 APRD00625
DocetaxelDB01248 APRD00932

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019140MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21562774The iPSC clones could differentiate to cells originated from all three germ-cell layers, as shown by RT-PCR, for messenger RNA (mRNA) expression of alpha-fetoprotein (endoderm), MSX1 (mesoderm) and microtubule-associated protein 2 (ectoderm), and by immunostaining for alpha-fetoprotein (endoderm), alpha-smooth muscle actin (mesoderm), and beta-III-tubulin (ectoderm)
18358537An OBGF400 neuronal phenotype was indicated by the recognition of a transfected neuronal progenitor-cell-specific tubulin-alpha1 gene promoter, intracellular presence of early neuronal markers (TuJ1, neuregulin-1, doublecortin and SOX2) and enhanced expression of neuronal- and progenitor lineage-active genes (MAP2, nestin, ENO and Syn1) compared to that of porcine epithelial cells
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