HCSGD entry for MAOA

1. General information

Official gene symbolMAOA
Entrez ID4128
Gene full namemonoamine oxidase A
Other gene symbolsMAO-A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005741Mitochondrial outer membraneTAScellular_component
GO:0006576Cellular biogenic amine metabolic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0007610BehaviorTASbiological_process
GO:0008131Primary amine oxidase activityTASmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0042135Neurotransmitter catabolic processIEAbiological_process
GO:0042136Neurotransmitter biosynthetic processTASbiological_process
GO:0042420Dopamine catabolic processIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27936654760.04852978990.97626109640.4121711935

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0110290399
GSE13712_SHEARDown-0.8856013246
GSE13712_STATICDown-0.7213529531
GSE19018Down-0.2604970729
GSE19899_A1Up0.0291876597
GSE19899_A2Up0.5277538372
PubMed_21979375_A1Up2.0533331269
PubMed_21979375_A2Up0.4036714015
GSE35957Up0.3559264738
GSE36640Down-0.0643402260
GSE54402Down-0.2624056609
GSE9593Down-0.1716378107
GSE43922Down-0.0666075248
GSE24585Down-1.2601874207
GSE37065Up0.0389213178
GSE28863_A1Down-0.2768731386
GSE28863_A2Up0.2051467728
GSE28863_A3Up0.3074046289
GSE28863_A4Up0.0123197627
GSE48662Up0.0001458901

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhentermineDB00191 APRD00093
TranylcypromineDB00752 APRD00645
PhenelzineDB00780 APRD00099
MinaprineDB00805 APRD00735
ZonisamideDB00909 APRD00004
SelegilineDB01037 APRD00525
IsocarboxazidDB01247 APRD00701
EphedraDB01363 -
MMDADB01442 -
4-MethoxyamphetamineDB01472 EXPT03303
PargylineDB01626 -
N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)PropylamineDB04017 EXPT02182
ZimelidineDB04832 -
PosizolidDB04850 -
CX157DB05205 -
DECYL(DIMETHYL)PHOSPHINE OXIDEDB07641 -
7-METHOXY-1-METHYL-9H-BETA-CARBOLINEDB07919 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-22-3pMIMAT0000077MIRT005902Luciferase reporter assay//MicroarrayFunctional MTI21168126
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

9564604Relationship between monoamine oxidase (MAO) A specific activity and proportion of human skin fibroblasts which express the enzyme in culture
9564604Total deficiency of monoamine oxidase A (MAO-A) in affected males of a single, human kindred appears to be associated with mild mental retardation and significant behavioral anomalies
9564604Though total MAO-A deficiency appears to be rare, the extent and significance of individual variation in monoamine oxidase A activity in human populations is unclear
9564604Since MAO-A activity is undetectable in blood cells, most systematic surveys of individual variation MAO-A activity have compared enzyme activity in human fibroblasts cultured from skin biopsies
9564604Surprisingly, MAO-A activity in skin fibroblast cultures from unrelated donors ranges over 100-fold
9564604It has been suggested that this extreme variation in fibroblast MAO-A activity between donors reflects individual, genetic variation in the regulation of MAO-A in fibroblasts
9564604I have found from studies with immunofluorescence microscopy and flow cytometry that the proportion of MAO-A+ cells in fibroblast cultures is (a) highly variable between cultures, (b) a reproducible characteristic of each culture and (c) the primary factor responsible for variation in MAO-A specific activity in whole cell, skin fibroblast homogenates
9564604It has been shown previously that MAO-A activity of a skin fibroblast culture is relatively constant with continued passage prior to cellular senescence
9564604Therefore, these new data raise the possibility that MAO-A expression is confined to a functionally distinct subset of human skin fibroblasts
3731213Two forms of monoamine oxidase (MAO A and MAO B) exist which, although similar in a number of properties, can be distinguished on the basis of their substrate specificity, inhibitor sensitivity, kinetic parameters, and protein structure
3731213These properties were used to study the molecular mechanism(s) by which glucocorticoid hormones and "aging," known to alter MAO activity in vivo, regulated the expression of MAO A and MAO B in cultured human skin fibroblasts
3731213The 6- to 14-fold increases in total activity were paralleled by similar increases in the activity and amount of active MAO A but less than 2- to 3-fold increases in the activity and amount of MAO B
3731213In summary, we have shown that glucocorticoids and cellular aging selectively affect the amount of MAO A at the level of active enzyme synthesis or degradation
3731213Further, our finding that the expression of the two forms of MAO in human fibroblasts can be independently regulated supports the growing evidence that MAO A and MAO B are separate molecular entities
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