HCSGD entry for ARSA

1. General information

Official gene symbolARSA
Entrez ID410
Gene full namearylsulfatase A
Other gene symbolsMLD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001669Acrosomal vesicleIEAcellular_component
GO:0004065Arylsulfatase activityIEAmolecular_function
GO:0004098Cerebroside-sulfatase activityTASmolecular_function
GO:0005509Calcium ion bindingIDAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005764LysosomeTAScellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0006665Sphingolipid metabolic processTASbiological_process
GO:0006687Glycosphingolipid metabolic processTASbiological_process
GO:0006914AutophagyIEAbiological_process
GO:0007339Binding of sperm to zona pellucidaIEAbiological_process
GO:0007417Central nervous system developmentIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008484Sulfuric ester hydrolase activityIDAmolecular_function
GO:0009268Response to pHIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0031232Extrinsic component of external side of plasma membraneIEAcellular_component
GO:0043202Lysosomal lumenTAScellular_component
GO:0043627Response to estrogenIEAbiological_process
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0051597Response to methylmercuryIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33255459900.60437417650.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1319200238
GSE13712_SHEARDown-0.1432184174
GSE13712_STATICUp0.1675333473
GSE19018Up0.0265553869
GSE19899_A1Down-0.1574789400
GSE19899_A2Up0.0333587107
PubMed_21979375_A1Down-0.3339471455
PubMed_21979375_A2Up0.2530099648
GSE35957Down-0.3387144585
GSE36640Up0.2382488608
GSE54402Down-0.1214093422
GSE9593Up0.2159539237
GSE43922Down-0.0760094438
GSE24585Up0.5182869094
GSE37065Down-0.1439826663
GSE28863_A1Up0.1703076816
GSE28863_A2Up0.1777332478
GSE28863_A3Up0.2284218458
GSE28863_A4Down-0.0567415347
GSE48662Up0.5381558895

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)BenzenaminiumDB01800 EXPT01034
2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic AcidDB03821 EXPT01431

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018147MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

522513Arylsulfatase A, beta-D-galactosidase and beta-D-glucuronidase activities were significantly lower and arylsulfatase B activity was significantly higher in senescent cells than in actively growing cells
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