HCSGD entry for SMAD6

1. General information

Official gene symbolSMAD6
Entrez ID4091
Gene full nameSMAD family member 6
Other gene symbolsAOVD2 HsT17432 MADH6 MADH7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001657Ureteric bud developmentIEAbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006955Immune responseIMPbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEAbiological_process
GO:0007352Zygotic specification of dorsal/ventral axisIMPbiological_process
GO:0008285Negative regulation of cell proliferationIMPbiological_process
GO:0010991Negative regulation of SMAD protein complex assemblyIDAbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIMPbiological_process
GO:0030514Negative regulation of BMP signaling pathwayIDAbiological_process
GO:0030617Transforming growth factor beta receptor, inhibitory cytoplasmic mediator activityIDA IMPmolecular_function
GO:0031589Cell-substrate adhesionIMPbiological_process
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0034616Response to laminar fluid shear stressIEPbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingIDAmolecular_function
GO:0035556Intracellular signal transductionIDA IMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043627Response to estrogenIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060394Negative regulation of pathway-restricted SMAD protein phosphorylationIDA IMPbiological_process
GO:0070410Co-SMAD bindingIPImolecular_function
GO:0070411I-SMAD bindingIPImolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
GO:0070698Type I activin receptor bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96338731050.01810551650.99999024730.2633632450

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1915963583
GSE13712_SHEARDown-0.3430956648
GSE13712_STATICDown-0.6862814818
GSE19018Down-0.1755420672
GSE19899_A1Down-0.1602052222
GSE19899_A2Down-0.5377756475
PubMed_21979375_A1Down-0.7582456661
PubMed_21979375_A2Down-0.5909472930
GSE35957Down-0.0107686531
GSE36640Up0.1041245087
GSE54402Down-0.2672992732
GSE9593Down-0.0869645434
GSE43922Down-0.1988155128
GSE24585Down-0.5080163430
GSE37065Up0.1914894166
GSE28863_A1Up0.0438121260
GSE28863_A2Down-0.3898355481
GSE28863_A3Down-0.1291656111
GSE28863_A4Up0.2250813663
GSE48662Up0.4777582274

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-520hMIMAT0002867MIRT001951Microarray;OtherFunctional MTI (Weak)18189265
hsa-miR-26b-5pMIMAT0000083MIRT030225MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26981207Bmp2-Smad inhibitor Smad6 was strongly repressed with H3K4me3 loss in Raf-induced senescence, as detected in Ras-induced senescence, and senescence was also bypassed by Smad6 induction in Raf-activated cells
26981207Different from Ras-induced senescence, however, gain of H3K27me3 did not occur in the Smad6 promoter region during Raf-induced senescence
26981207CONCLUSION: Although epigenetic alterations are partly different, Bmp2 upregulation and Smad6 repression occur and contribute to Raf-induced senescence, as detected in Ras-induced senescence
22072987Bmp2 was the most activated secreted factor with H3K4me3 gain and H3K27me3 loss, whereas H3K4me3 loss and de novo formation of H3K27me3 occurred inversely in repression of nine genes, including two BMP-SMAD inhibitors Smad6 and Noggin
22072987Senescence was bypassed in Ras-activated cells when Bmp2/Smad1 signal was blocked by Bmp2 knockdown, Smad6 induction, or Noggin induction
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