HCSGD entry for SMAD5

1. General information

Official gene symbolSMAD5
Entrez ID4090
Gene full nameSMAD family member 5
Other gene symbolsDWFC JV5-1 MADH5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001880Mullerian duct regressionIEAbiological_process
GO:0002051Osteoblast fate commitmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005057Receptor signaling protein activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEA NAScellular_component
GO:0005634NucleusIEA NAS TAScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationIEAbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIEA NASbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0009880Embryonic pattern specificationISSbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0030509BMP signaling pathwayISS TASbiological_process
GO:0030618Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityTASmolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0035556Intracellular signal transductionNAS TASbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051216Cartilage developmentIEAbiological_process
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0060348Bone developmentIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071773Cellular response to BMP stimulusIEA ISSbiological_process
GO:1901522Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63606141860.46740603320.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0441286306
GSE13712_SHEARUp0.3715492621
GSE13712_STATICUp0.2767318787
GSE19018Down-0.1153834446
GSE19899_A1Up0.0640655111
GSE19899_A2Down-0.0130514081
PubMed_21979375_A1Down-0.1382934122
PubMed_21979375_A2Up0.2003352185
GSE35957Up0.1344322097
GSE36640Down-0.0991331049
GSE54402Up0.0619227828
GSE9593Up0.0050739304
GSE43922Down-0.0032646520
GSE24585Down-0.0070763966
GSE37065Down-0.1700352967
GSE28863_A1Down-0.0293080343
GSE28863_A2Up0.2499356103
GSE28863_A3Down-0.5379981653
GSE28863_A4Down-0.2432869769
GSE48662Up0.0963950204

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT000973Luciferase reporter assayFunctional MTI18367535
hsa-miR-155-5pMIMAT0000646MIRT000973immunoblot//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20133617
hsa-miR-155-5pMIMAT0000646MIRT000973Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20427544
hsa-miR-155-5pMIMAT0000646MIRT000973ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT002600MicroarrayFunctional MTI (Weak)15685193
hsa-miR-130a-3pMIMAT0000425MIRT007143qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-186-5pMIMAT0000456MIRT021198SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031637ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.