HCSGD entry for SMAD3

1. General information

Official gene symbolSMAD3
Entrez ID4088
Gene full nameSMAD family member 3
Other gene symbolsHSPC193 HsT17436 JV15-2 LDS1C LDS3 MADH3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEA IMP TASbiological_process
GO:0000987Core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0000988Protein binding transcription factor activityIDAmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001666Response to hypoxiaIMPbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001756SomitogenesisIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001933Negative regulation of protein phosphorylationIMPbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0002520Immune system developmentIEAbiological_process
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005160Transforming growth factor beta receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005637Nuclear inner membraneIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006810TransportIDAbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0006955Immune responseIMPbiological_process
GO:0007050Cell cycle arrestIMPbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDA IEA TASbiological_process
GO:0007183SMAD protein complex assemblyIDA IEAbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0008134Transcription factor bindingIEA IPImolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009880Embryonic pattern specificationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010694Positive regulation of alkaline phosphatase activityIEAbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDA IMPbiological_process
GO:0016202Regulation of striated muscle tissue developmentIEAbiological_process
GO:0017015Regulation of transforming growth factor beta receptor signaling pathwayIEA IMPbiological_process
GO:0019049Evasion or tolerance of host defenses by virusIDAbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0019902Phosphatase bindingIPImolecular_function
GO:0023019Signal transduction involved in regulation of gene expressionIEAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030501Positive regulation of bone mineralizationIEAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0030618Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityIDAmolecular_function
GO:0030878Thyroid gland developmentIEAbiological_process
GO:0031053Primary miRNA processingTASbiological_process
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0032332Positive regulation of chondrocyte differentiationIEAbiological_process
GO:0032731Positive regulation of interleukin-1 beta productionIEAbiological_process
GO:0032909Regulation of transforming growth factor beta2 productionIMPbiological_process
GO:0032916Positive regulation of transforming growth factor beta3 productionIEAbiological_process
GO:0032924Activin receptor signaling pathwayIMPbiological_process
GO:0033689Negative regulation of osteoblast proliferationIEAbiological_process
GO:0035413Positive regulation of catenin import into nucleusIMPbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0038092Nodal signaling pathwayIMPbiological_process
GO:0042060Wound healingTASbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0042177Negative regulation of protein catabolic processIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0042993Positive regulation of transcription factor import into nucleusIDAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0043235Receptor complexIMPcellular_component
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045216Cell-cell junction organizationIMPbiological_process
GO:0045668Negative regulation of osteoblast differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045930Negative regulation of mitotic cell cycleIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEA IMP TASbiological_process
GO:0046332SMAD bindingIEAmolecular_function
GO:0048340Paraxial mesoderm morphogenesisIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0048617Embryonic foregut morphogenesisIEAbiological_process
GO:0048701Embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0050678Regulation of epithelial cell proliferationIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIEAbiological_process
GO:0050776Regulation of immune responseIEAbiological_process
GO:0050821Protein stabilizationIMPbiological_process
GO:0050927Positive regulation of positive chemotaxisIEAbiological_process
GO:0051098Regulation of bindingIEAbiological_process
GO:0051496Positive regulation of stress fiber assemblyIEAbiological_process
GO:0051894Positive regulation of focal adhesion assemblyIEAbiological_process
GO:0060039Pericardium developmentIEAbiological_process
GO:0060290TransdifferentiationIEAbiological_process
GO:0061045Negative regulation of wound healingIEAbiological_process
GO:0070306Lens fiber cell differentiationIEAbiological_process
GO:0070410Co-SMAD bindingIPImolecular_function
GO:0070412R-SMAD bindingIPImolecular_function
GO:0071141SMAD protein complexIDAcellular_component
GO:0090263Positive regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIMPbiological_process
GO:0097296Activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEAbiological_process
GO:1901313Positive regulation of gene expression involved in extracellular matrix organizationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46766588280.00551589230.99999024730.1504495337

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0431348193
GSE13712_SHEARUp0.8219478242
GSE13712_STATICUp1.1245407445
GSE19018Down-0.0676383627
GSE19899_A1Down-1.2981458855
GSE19899_A2Down-0.4031561622
PubMed_21979375_A1Down-3.1564428213
PubMed_21979375_A2Down-1.3068426515
GSE35957Down-0.6424264764
GSE36640Down-0.9292506231
GSE54402Down-1.5315469039
GSE9593Up0.3700379461
GSE43922Down-1.0025286036
GSE24585Down-0.2389894002
GSE37065Down-0.3385452254
GSE28863_A1Up0.4525886852
GSE28863_A2Up0.2147770167
GSE28863_A3Up0.0912684788
GSE28863_A4Up0.0867020679
GSE48662Up0.3060273793

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200a-3pMIMAT0000682MIRT007291Luciferase reporter assayFunctional MTI22020340
hsa-miR-18a-5pMIMAT0000072MIRT007323Western blotFunctional MTI23249750
hsa-miR-335-5pMIMAT0000765MIRT018567MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020918Western blotNon-Functional MTI21036908
hsa-miR-193b-3pMIMAT0002819MIRT041360CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050933CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24925089Moreover, JMJD3 can activate TGF-beta signaling through the SMAD3 pathway
20049743We find that satellite cells are maintained in aged human skeletal muscle, but fail to activate in response to muscle attrition, due to diminished activation of Notch compounded by elevated transforming growth factor beta (TGF-beta)/phospho Smad3 (pSmad3)
19643742Bone morphogenetic protein-7 induces telomerase inhibition, telomere shortening, breast cancer cell senescence, and death via Smad3
19193721Bone morphogenetic protein-7 induces telomerase inhibition, telomere shortening, breast cancer cell senescence, and death via Smad3
19193721Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces Smad3 phosphorylation, nuclear translocation, and hTERT gene repression
17473528The mRNA expressions of Smad3 increased, but those of c-myc and nucleostemin decreased with the length hMSCs were in in vitro culture
15356634These cells also have impaired phosphorylation and nuclear translocation of the TGF-beta signalling proteins Smad2 and Smad3, as well as impaired induction of TGF-beta target genes
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