HCSGD entry for MARCKS
1. General information
| Official gene symbol | MARCKS |
|---|---|
| Entrez ID | 4082 |
| Gene full name | myristoylated alanine-rich protein kinase C substrate |
| Other gene symbols | 80K-L MACS PKCSL PRKCSL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005080 | Protein kinase C binding | IEA | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005813 | Centrosome | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0015629 | Actin cytoskeleton | TAS | cellular_component |
| GO:0042585 | Germinal vesicle | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
| GO:0051015 | Actin filament binding | TAS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9755165457 | 0.0012775047 | 0.9999902473 | 0.0683439024 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6369258994 |
| GSE13712_SHEAR | Up | 0.1285307909 |
| GSE13712_STATIC | Down | -0.2579403604 |
| GSE19018 | Down | -0.1087661319 |
| GSE19899_A1 | Down | -1.1686247623 |
| GSE19899_A2 | Down | -1.0160364231 |
| PubMed_21979375_A1 | Down | -2.1243511023 |
| PubMed_21979375_A2 | Down | -2.2096661145 |
| GSE35957 | Down | -0.7458958724 |
| GSE36640 | Down | -1.0024534688 |
| GSE54402 | Down | -0.6828632410 |
| GSE9593 | Down | -0.2234892877 |
| GSE43922 | Down | -0.5893231811 |
| GSE24585 | Down | -0.1560904298 |
| GSE37065 | Down | -0.3717750432 |
| GSE28863_A1 | Up | 0.8870329889 |
| GSE28863_A2 | Up | 0.3082624182 |
| GSE28863_A3 | Up | 0.0996125663 |
| GSE28863_A4 | Down | -0.4772317330 |
| GSE48662 | Down | -0.1928320893 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT001221 | Luciferase reporter assay//Western blot | Functional MTI | 19302977 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020762 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023285 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1 | MIMAT0000416 | MIRT023806 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037313 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046418 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | 1 | hsa-miR-21 | {Western blot} | {downregulation by anti-miRNA oligonucleotide} | 19302977 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 8 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27081703 | MARCKS contributes to stromal cancer-associated fibroblast activation and facilitates ovarian cancer metastasis |
| 27081703 | Here, we determined that myristoylated alanine-rich C-kinase substrate (MARCKS) was highly expressed in ovarian stroma, and was required for the differentiation and tumor promoting function of CAFs |
| 27081703 | Suppression of MARCKS resulted in the loss of CAF features, and diminished role of CAFs in supporting tumor cell growth in 3D organotypic cultures and in murine xenograft model |
| 27081703 | Mechanistically, we found that MARCKS maintained CAF activation through suppression of cellular senescence and activation of the AKT/Twist1 signaling |
| 27081703 | Moreover, high MARCKS expression was associated with poor patient survival in EOC |
| 27081703 | Collectively, our findings identify the potential of MARCKS inhibition as a novel stroma-oriented therapy in EOC |
| 26084179 | METHOD: Sca-1 + HSC/HPC was isolated by magnetic cell sorting (MACS) and divided into five groups: the normal control group, the aging group, the positive control group, the Rg1 anti-senescence group, and the Rg1-treated group |
| 25993799 | METHOD: Acute myelogenous leukemia stem cells were isolated by magnetic activated cell sorting (MACS) |
| 25688074 | Demographic, clinical and laboratory parameters were collected in all patients and we isolated naive (CD45RA(+)) and memory (CD45RO(+)) CD4(+) and CD8(+) T-cell subsets by MACS technology |
| 24335839 | Sca-1(+) HSC/HPCs were isolated and purified from their bone marrow using MACS |
| 23643076 | Thereafter, Sca-1(+);HSC/HPC were isolated by magnetic-activated cell sorting (MACS) from bone marrow of all the mice |
| 23643076 | RESULTS: The purity of Sca-1(+);HSC/HPC reached 94% after MACS |
| 21657082 | METHOD: Sca-1 + HSC was isolated by magnetic cell sorting (MACS) and divided into five groups |
| 8536797 | The life span of the biotin-conjugated cells was found to be normal (approximately 110 days), and the stability of the biotin ligand was adequate for efficient retrieval of cells using avidin-coated magnetic beads (magnetic cell sorting [MACS]) |
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