HCSGD entry for M6PR
1. General information
| Official gene symbol | M6PR |
|---|---|
| Entrez ID | 4074 |
| Gene full name | mannose-6-phosphate receptor (cation dependent) |
| Other gene symbols | CD-MPR MPR 46 MPR-46 MPR46 SMPR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000323 | Lytic vacuole | IEA | cellular_component |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0005537 | Mannose binding | IEA | molecular_function |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005768 | Endosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006898 | Receptor-mediated endocytosis | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008333 | Endosome to lysosome transport | TAS | biological_process |
| GO:0015578 | Mannose transmembrane transporter activity | IEA | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0765767068 | 0.6268161886 | 0.5854125762 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9404143990 |
| GSE13712_SHEAR | Up | 0.3564378994 |
| GSE13712_STATIC | Up | 0.0742875039 |
| GSE19018 | Down | -0.2735895877 |
| GSE19899_A1 | Down | -0.0976436041 |
| GSE19899_A2 | Up | 0.5267213494 |
| PubMed_21979375_A1 | Down | -0.5871917641 |
| PubMed_21979375_A2 | Up | 0.4369928493 |
| GSE35957 | Down | -0.0669778174 |
| GSE36640 | Down | -0.2519189653 |
| GSE54402 | Up | 0.4552963751 |
| GSE9593 | Up | 0.6779501014 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Up | 0.0388885151 |
| GSE28863_A2 | Up | 0.4321392056 |
| GSE28863_A3 | Down | -0.4946937458 |
| GSE28863_A4 | Up | 0.1803551932 |
| GSE48662 | Down | -0.6689782040 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alglucosidase alfa | DB01272 | - |
| 1-3 Sugar Ring of Pentamannosyl 6-Phosphate | DB02755 | EXPT02479 |
| alpha-D-mannose 6-phosphate | DB02900 | EXPT02088 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005835 | Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21282569 |
| hsa-miR-484 | MIMAT0002174 | MIRT041910 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045509 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
