HCSGD entry for LUM
1. General information
| Official gene symbol | LUM |
|---|---|
| Entrez ID | 4060 |
| Gene full name | lumican |
| Other gene symbols | LDC SLRR2D |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005201 | Extracellular matrix structural constituent | NAS | molecular_function |
| GO:0005518 | Collagen binding | IDA | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | TAS | cellular_component |
| GO:0005583 | Fibrillar collagen | IDA | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0014070 | Response to organic cyclic compound | IEA | biological_process |
| GO:0018146 | Keratan sulfate biosynthetic process | TAS | biological_process |
| GO:0030199 | Collagen fibril organization | NAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA ISS | cellular_component |
| GO:0042339 | Keratan sulfate metabolic process | TAS | biological_process |
| GO:0042340 | Keratan sulfate catabolic process | TAS | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0051216 | Cartilage development | IEA | biological_process |
| GO:0070848 | Response to growth factor | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0470575586 | 0.0096870256 | 0.4802644436 | 0.1948280153 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0403331607 |
| GSE13712_SHEAR | Down | -0.1325455805 |
| GSE13712_STATIC | Down | -1.4194839713 |
| GSE19018 | Down | -1.5284272660 |
| GSE19899_A1 | Down | -0.1010048257 |
| GSE19899_A2 | Down | -1.6835478350 |
| PubMed_21979375_A1 | Down | -0.1264650983 |
| PubMed_21979375_A2 | Down | -0.8541176508 |
| GSE35957 | Up | 0.0656551162 |
| GSE36640 | Up | 1.3825350867 |
| GSE54402 | Down | -2.0040571316 |
| GSE9593 | Up | 0.2798807905 |
| GSE43922 | Down | -0.7902725064 |
| GSE24585 | Up | 0.5056266668 |
| GSE37065 | Up | 0.1857399929 |
| GSE28863_A1 | Up | 0.5736825791 |
| GSE28863_A2 | Up | 1.1552518757 |
| GSE28863_A3 | Down | -0.3339846277 |
| GSE28863_A4 | Up | 0.5562640417 |
| GSE48662 | Up | 0.3593385282 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15958393 | Collagen alpha1(VI), collagen alpha2(I), fibronectin, lumican, and matrix metalloproteinase 2 were among the proteins consistently detected from control and H2O2-treated cells |
| 11344338 | The MK/T-1 cells express vimentin, tubulin, lumican, mimecan, decorin and collagen I, but not keratocan |
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