HCSGD entry for ARNTL
1. General information
| Official gene symbol | ARNTL |
|---|---|
| Entrez ID | 406 |
| Gene full name | aryl hydrocarbon receptor nuclear translocator-like |
| Other gene symbols | BMAL1 BMAL1c JAP3 MOP3 PASD3 TIC bHLHe5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000060 | Protein import into nucleus, translocation | IEA | biological_process |
| GO:0000982 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity | IEA ISS | molecular_function |
| GO:0001047 | Core promoter binding | ISS | molecular_function |
| GO:0001190 | RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA IGI | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA IPI | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0007623 | Circadian rhythm | TAS | biological_process |
| GO:0016604 | Nuclear body | IEA | cellular_component |
| GO:0017162 | Aryl hydrocarbon receptor binding | IPI | molecular_function |
| GO:0032922 | Circadian regulation of gene expression | IEA ISS | biological_process |
| GO:0042176 | Regulation of protein catabolic process | IEA | biological_process |
| GO:0043425 | BHLH transcription factor binding | IEA | molecular_function |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IGI | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0046983 | Protein dimerization activity | IEA | molecular_function |
| GO:0051879 | Hsp90 protein binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0748606626 | 0.5138653357 | 0.5797844660 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2642126714 |
| GSE13712_SHEAR | Up | 0.2284905236 |
| GSE13712_STATIC | Down | -0.1498152098 |
| GSE19018 | Down | -0.2888956647 |
| GSE19899_A1 | Up | 0.0673456780 |
| GSE19899_A2 | Up | 0.5771370055 |
| PubMed_21979375_A1 | Up | 0.4557689308 |
| PubMed_21979375_A2 | Up | 0.3446202010 |
| GSE35957 | Down | -0.5423467878 |
| GSE36640 | Down | -0.6864232108 |
| GSE54402 | Up | 0.3419962244 |
| GSE9593 | Down | -0.2902997000 |
| GSE43922 | Up | 0.8359541145 |
| GSE24585 | Up | 0.4642997788 |
| GSE37065 | Up | 0.3929612482 |
| GSE28863_A1 | Down | -0.1235358097 |
| GSE28863_A2 | Up | 0.1842765413 |
| GSE28863_A3 | Down | -0.3978112777 |
| GSE28863_A4 | Down | -0.0094084757 |
| GSE48662 | Down | -0.1695740656 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-494-3p | MIMAT0002816 | MIRT006653 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21799909 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT006654 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21799909 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT006654 | Luciferase reporter assay | Functional MTI | 22958478 |
| hsa-miR-142-3p | MIMAT0000434 | MIRT006654 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018183 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26961881 | In contrast, mouse embryonic fibroblasts prepared from mice deficient in positive circadian clock regulators, Bmal1 or Clock, showed resistance to oncogene-induced transformation |
| 26361874 | The key nuclear receptors and transcription factors REV-ERBalpha and RORalpha regulate Bmal1 expression and provide stability to the oscillator |
| 26361874 | The deacetylase Sirtuin 1 (SIRT1) regulates the timing of the clock through acetylation of BMAL1 and PER2 and controls the clock-dependent functions, which can also be affected by environmental stressors |
| 26199639 | Bavachalcone Enhances RORalpha Expression, Controls Bmal1 Circadian Transcription, and Depresses Cellular Senescence in Human Endothelial Cells |
| 26199639 | In addition, bavachalcone induced RORalpha1 expression in mRNA and protein levels in a dose-dependent manner and enhanced the circadian amplitude of Bmal1 mRNA expression after serum shock |
| 25938935 | Stress-mediated post-translational modification of molecular clock proteins, brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) and PERIOD 2, is associated with a reduction in the activity/level of the deacetylase sirtuin 1 (SIRT1) |
| 25938935 | Similarly, the levels of the nuclear receptor REV-ERBalpha and retinoic acid receptor-related orphan receptor alpha (ROR alpha), critical regulators of Bmal1 expression, are altered by environmental stresses |
| 22457671 | Age-related BMAL1 change affects mouse bone marrow stromal cell proliferation and osteo-differentiation potential |
| 22457671 | Due to recent research's indication that a core circadian component, brain and muscle ARNT-like 1 protein (BMAL1), has a role in premature aging, we investigated the normal aging mechanism in mice with their MSCs and Bmal1 gene/protein level |
| 22457671 | Bmal1 gene and protein level were detected in these cells |
| 22457671 | RESULTS: Bmal1 gene and protein level as well as S-phase fraction of the cell cycle decreased in MSCs along with the aging process |
| 22457671 | CONCLUSIONS: These findings demonstrate that mouse MSCs changed with their proliferation and osteo-differentiation abilities at different aging stages, and that Bmal1 is related to the normal aging process in MSCs |
| 22101268 | Deficiency of the circadian clock transcriptional factor BMAL1 results in the development of premature aging in mice |
| 22101268 | In agreement with the accelerated aging phenotype, we observed an increase in the number of senescent cells in different tissues (lungs, liver and spleen) of Bmal1(-/-) mice, which suggests the important role of BMAL1 in the control of senescence in vivo |
| 22101268 | However, no difference in the rate of proliferation and senescence between primary fibroblasts isolated from wild-type and Bmal1(-/-) mice has been detected, suggesting that BMAL1 does not play a significant role in replicative senescence in vitro |
| 22101268 | BMAL1 deficient fibroblasts had an increased sensitivity to hydrogen peroxide treatment, and reduced sensitivity to DNA damaging anticancer drugs etoposide and daunorubicin |
| 22101268 | We propose that BMAL1 is important for the regulation of oxidative stress and DNA damage responses, while deregulation of these processes upon BMAL1 deficiency leads to development of stress induced senescence in vivo |
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