HCSGD entry for LTK

1. General information

Official gene symbolLTK
Entrez ID4058
Gene full nameleukocyte receptor tyrosine kinase
Other gene symbolsTYK1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004672Protein kinase activityIDAmolecular_function
GO:0004713Protein tyrosine kinase activityTASmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayIEAbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0010666Positive regulation of cardiac muscle cell apoptotic processIDAbiological_process
GO:0010976Positive regulation of neuron projection developmentIMPbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIMPbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0071300Cellular response to retinoic acidIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61982678470.76301839220.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1554455222
GSE13712_SHEARUp0.1248061272
GSE13712_STATICDown-0.0314441530
GSE19018Up0.0050412151
GSE19899_A1Down-0.0036737372
GSE19899_A2Up0.0355060656
PubMed_21979375_A1Down-0.0868849899
PubMed_21979375_A2Down-0.0877144327
GSE35957Up0.1072594488
GSE36640Up0.0983325917
GSE54402Up0.0554887170
GSE9593Down-0.0448450361
GSE43922Up0.0459172627
GSE24585Up0.1037487842
GSE37065Up0.0410366862
GSE28863_A1Down-0.1614848181
GSE28863_A2Down-0.2116899911
GSE28863_A3Up0.4075408687
GSE28863_A4Up0.1480352604
GSE48662Up0.1774455939

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018950MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.