HCSGD entry for LTF

1. General information

Official gene symbolLTF
Entrez ID4057
Gene full namelactotransferrin
Other gene symbolsGIG12 HLF2 LF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001503OssificationIEAbiological_process
GO:0001817Regulation of cytokine productionIDAbiological_process
GO:0002227Innate immune response in mucosaIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0004252Serine-type endopeptidase activityTASmolecular_function
GO:0005506Iron ion bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006508ProteolysisIEAbiological_process
GO:0006826Iron ion transportIEAbiological_process
GO:0006879Cellular iron ion homeostasisIEAbiological_process
GO:0006959Humoral immune responseTASbiological_process
GO:0008199Ferric iron bindingIEAmolecular_function
GO:0008201Heparin bindingIDAmolecular_function
GO:0008233Peptidase activityIEAmolecular_function
GO:0019731Antibacterial humoral responseIDAbiological_process
GO:0019732Antifungal humoral responseIDAbiological_process
GO:0030141Secretory granuleIDAcellular_component
GO:0031665Negative regulation of lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0032680Regulation of tumor necrosis factor productionIDAbiological_process
GO:0033214Iron assimilation by chelation and transportTASbiological_process
GO:0033690Positive regulation of osteoblast proliferationIDAbiological_process
GO:0034145Positive regulation of toll-like receptor 4 signaling pathwayIMPbiological_process
GO:0042581Specific granuleIDAcellular_component
GO:0043066Negative regulation of apoptotic processISSbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043539Protein serine/threonine kinase activator activityIDAmolecular_function
GO:0045669Positive regulation of osteoblast differentiationIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0051701Interaction with hostTASbiological_process
GO:0052572Response to host immune responseTASbiological_process
GO:0060349Bone morphogenesisIDAbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIDAbiological_process
GO:0090382Phagosome maturationTASbiological_process
GO:0097013Phagocytic vesicle lumenTAScellular_component
GO:1900159Positive regulation of bone mineralization involved in bone maturationISSbiological_process
GO:1900229Negative regulation of single-species biofilm formation in or on host organismIDAbiological_process
GO:2000308Negative regulation of tumor necrosis factor (ligand) superfamily member 11 productionISSbiological_process
GO:2001205Negative regulation of osteoclast developmentISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19880245050.90557202230.86147360541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0544462331
GSE13712_SHEARDown-0.0451958260
GSE13712_STATICUp0.2123487016
GSE19018Up0.2840054686
GSE19899_A1Down-0.0911815551
GSE19899_A2Down-0.0273551435
PubMed_21979375_A1Up0.2338328453
PubMed_21979375_A2Up0.1562319315
GSE35957Up1.0005229922
GSE36640Up0.0318384073
GSE54402Up0.0612825255
GSE9593Down-0.0411751822
GSE43922Up0.2209087083
GSE24585Up0.2681761456
GSE37065Down-0.0663938756
GSE28863_A1Down-0.0759856856
GSE28863_A2Up0.1082810002
GSE28863_A3Up0.1649316796
GSE28863_A4Down-0.0408431899
GSE48662Down-0.0557594521

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

3h-Indole-5,6-DiolDB01811 EXPT00174
Nitrilotriacetic AcidDB03040 EXPT02390
Alpha-D-FucoseDB03485 EXPT01400
NimesulideDB04743 -
2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDEDB06987 -
ParecoxibDB08439 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23801923These bind to the polylactosaminyl oligosaccharide, a carbohydrate that exists in lactoferrin and in the 38-kDa fragment of band 3 protein
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