HCSGD entry for LTBP2
1. General information
| Official gene symbol | LTBP2 |
|---|---|
| Entrez ID | 4053 |
| Gene full name | latent transforming growth factor beta binding protein 2 |
| Other gene symbols | C14orf141 GLC3D LTBP3 MSPKA MSTP031 WMS3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0006605 | Protein targeting | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0008201 | Heparin binding | IEA | molecular_function |
| GO:0009306 | Protein secretion | TAS | biological_process |
| GO:0019838 | Growth factor binding | IEA | molecular_function |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0222105201 | 0.0455622621 | 0.3566827944 | 0.4005978993 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9642737960 |
| GSE13712_SHEAR | Up | 0.1317154720 |
| GSE13712_STATIC | Up | 0.3507834931 |
| GSE19018 | Down | -1.4366226944 |
| GSE19899_A1 | Up | 0.2889993126 |
| GSE19899_A2 | Down | -0.6711432949 |
| PubMed_21979375_A1 | Down | -1.6435150108 |
| PubMed_21979375_A2 | Down | -0.2924705217 |
| GSE35957 | Up | 0.1295478471 |
| GSE36640 | Up | 0.6380411251 |
| GSE54402 | Up | 0.3628448166 |
| GSE9593 | Up | 0.4139140777 |
| GSE43922 | Up | 0.0737532221 |
| GSE24585 | Up | 0.1569790513 |
| GSE37065 | Down | -0.5627874646 |
| GSE28863_A1 | Up | 1.2925457559 |
| GSE28863_A2 | Up | 1.6066612440 |
| GSE28863_A3 | Up | 0.4682516230 |
| GSE28863_A4 | Up | 0.0992769822 |
| GSE48662 | Down | -0.2555112037 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018706 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21740549 | Comparison of these known targets with genes known to be up-regulated upon senescence in these cells, by micro-array expression profiling, identified 4 common genes TMEM9B, ATXN10, LAYN and LTBP2/3 |
| 21740549 | CONCLUSION: The senescence bypass screen identified TMEM9B, ATXN10, LAYN and LTBP2/3 as novel downstream effectors of the p53-p21 and p16-pRB tumour suppressor pathways |
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