HCSGD entry for LTA

1. General information

Official gene symbolLTA
Entrez ID4049
Gene full namelymphotoxin alpha (TNF superfamily, member 1)
Other gene symbolsLT TNFB TNFSF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0002876Positive regulation of chronic inflammatory response to antigenic stimulusIEAbiological_process
GO:0002925Positive regulation of humoral immune response mediated by circulating immunoglobulinIEAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0048147Negative regulation of fibroblast proliferationIEAbiological_process
GO:0048535Lymph node developmentIEAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56141659890.66059368190.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0481745762
GSE13712_SHEARDown-0.0042754611
GSE13712_STATICDown-0.0223961309
GSE19018Down-0.0166809419
GSE19899_A1Down-0.0661380990
GSE19899_A2Up0.2718510240
PubMed_21979375_A1Down-0.0605926678
PubMed_21979375_A2Up0.1162654061
GSE35957Down-0.2095722787
GSE36640Up0.1799093357
GSE54402Up0.0788692390
GSE9593Up0.0436151768
GSE43922Up0.0819242240
GSE24585Up0.1664113950
GSE37065Down-0.0766515394
GSE28863_A1Down-0.1463134984
GSE28863_A2Down-0.3059194091
GSE28863_A3Up0.3264250149
GSE28863_A4Up0.0216996903
GSE48662Down-0.0281965605

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

EtanerceptDB00005 BTD00052 | BIOD00052

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

17199788In stepwise multiple linear regression, taking into consideration the most important characteristics of the HD patients and control group, the only significant predictors for percentage telomerase activity in PBMC were ox-LDL and TNF (beta = -0
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