HCSGD entry for LRP4
1. General information
| Official gene symbol | LRP4 |
|---|---|
| Entrez ID | 4038 |
| Gene full name | low density lipoprotein receptor-related protein 4 |
| Other gene symbols | CLSS LRP-4 LRP10 MEGF7 SOST2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001822 | Kidney development | IEA | biological_process |
| GO:0001932 | Regulation of protein phosphorylation | IEA | biological_process |
| GO:0001942 | Hair follicle development | IEA | biological_process |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006897 | Endocytosis | IEA | biological_process |
| GO:0009953 | Dorsal/ventral pattern formation | IEA | biological_process |
| GO:0009954 | Proximal/distal pattern formation | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030279 | Negative regulation of ossification | IMP | biological_process |
| GO:0030971 | Receptor tyrosine kinase binding | IEA | molecular_function |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0042733 | Embryonic digit morphogenesis | IEA | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0043113 | Receptor clustering | IEA | biological_process |
| GO:0051124 | Synaptic growth at neuromuscular junction | IEA | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0934548611 | 0.0398767942 | 0.6407683333 | 0.3763761563 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7541704185 |
| GSE13712_SHEAR | Down | -2.4858063270 |
| GSE13712_STATIC | Down | -1.4486439432 |
| GSE19018 | Down | -0.0968372415 |
| GSE19899_A1 | Up | 0.0620263306 |
| GSE19899_A2 | Up | 0.0392396316 |
| PubMed_21979375_A1 | Down | -0.8863576328 |
| PubMed_21979375_A2 | Up | 0.6258661795 |
| GSE35957 | Up | 0.0337829807 |
| GSE36640 | Down | -1.8384956696 |
| GSE54402 | Up | 1.2152070654 |
| GSE9593 | Down | -0.4415601903 |
| GSE43922 | Up | 0.0341417277 |
| GSE24585 | Down | -0.2285234953 |
| GSE37065 | Up | 0.0789321517 |
| GSE28863_A1 | Up | 0.5883446478 |
| GSE28863_A2 | Up | 0.9301368187 |
| GSE28863_A3 | Down | -0.0635433159 |
| GSE28863_A4 | Down | -0.1218232355 |
| GSE48662 | Down | -0.0977366015 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-197-3p | MIMAT0000227 | MIRT004194 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT004194 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019394 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029485 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
