HCSGD entry for LPO
1. General information
| Official gene symbol | LPO |
|---|---|
| Entrez ID | 4025 |
| Gene full name | lactoperoxidase |
| Other gene symbols | SPO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004601 | Peroxidase activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006979 | Response to oxidative stress | IEA NAS | biological_process |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0042744 | Hydrogen peroxide catabolic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8239996923 | 0.6550172828 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0280234708 |
| GSE13712_SHEAR | Down | -0.0246458673 |
| GSE13712_STATIC | Down | -0.0794158873 |
| GSE19018 | Down | -0.0791716087 |
| GSE19899_A1 | Down | -0.0865928212 |
| GSE19899_A2 | Up | 0.1392971377 |
| PubMed_21979375_A1 | Down | -0.2859141482 |
| PubMed_21979375_A2 | Up | 0.3368294464 |
| GSE35957 | Up | 0.0141739872 |
| GSE36640 | Down | -0.2007765328 |
| GSE54402 | Up | 0.1134384644 |
| GSE9593 | Up | 0.0886868611 |
| GSE43922 | Up | 0.0245603836 |
| GSE24585 | Up | 0.1235209253 |
| GSE37065 | Down | -0.0702320031 |
| GSE28863_A1 | Down | -0.0069684861 |
| GSE28863_A2 | Down | -0.0885525317 |
| GSE28863_A3 | Up | 0.1067605479 |
| GSE28863_A4 | Up | 0.0400725247 |
| GSE48662 | Down | -0.0535165940 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23763475 | H2 O2 increased the expression of stress defence genes, including catalase, cytochrome B alpha, lactoperoxidase and thioredoxin domain containing 2 |
| 21883446 | The separate studies were conducted to comparatively evaluate the sensitivity to oxidative stress and lipid peroxidation (LPO) of anterior chamber tissues including TM |
| 21883446 | Accumulation of the primary, secondary, and end products of LPO (diene and triene conjugates, Schiff's bases) was noted in the studied extracts |
| 21883446 | Significant differences in the levels of all mentioned LPO products in comparison with the control were observed |
| 21883446 | The data may be considered as an evidence of LPO participation in the destruction of the trabecule and Schlemm's canal in POAG |
| 16388826 | Apart from genetically programmed cell aging, different external aggressors related to oxidative stress and lipid peroxidation (LPO) can accelerate the skin aging phenomenon |
| 16388826 | 3-D molecular conformation studies proposed the antioxidant activity of peptidomimetics (carcinine, L-prolylhistamine, N-acetylcarnosine, L-carnosine) for metal ion binding, quenching of a number free radicals, and binding of hydroperoxide or aldehyde (including dialdehyde LPO products) in an imidazole-peroxide adducts |
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