HCSGD entry for ARL2
1. General information
| Official gene symbol | ARL2 |
|---|---|
| Entrez ID | 402 |
| Gene full name | ADP-ribosylation factor-like 2 |
| Other gene symbols | ARFL2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IMP | molecular_function |
| GO:0005095 | GTPase inhibitor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IMP | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005758 | Mitochondrial intermembrane space | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | IMP | biological_process |
| GO:0007021 | Tubulin complex assembly | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0008152 | Metabolic process | IMP | biological_process |
| GO:0010811 | Positive regulation of cell-substrate adhesion | ISS | biological_process |
| GO:0016328 | Lateral plasma membrane | ISS | cellular_component |
| GO:0031113 | Regulation of microtubule polymerization | IMP | biological_process |
| GO:0031116 | Positive regulation of microtubule polymerization | IDA | biological_process |
| GO:0034260 | Negative regulation of GTPase activity | IDA | biological_process |
| GO:0051297 | Centrosome organization | IMP | biological_process |
| GO:0051457 | Maintenance of protein location in nucleus | IDA | biological_process |
| GO:0070830 | Tight junction assembly | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9687639033 | 0.0122987690 | 0.9999902473 | 0.2188748479 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3062405468 |
| GSE13712_SHEAR | Down | -0.7985790377 |
| GSE13712_STATIC | Down | -0.6999259781 |
| GSE19018 | Up | 0.4318960229 |
| GSE19899_A1 | Down | -1.2417697047 |
| GSE19899_A2 | Down | -0.4992397127 |
| PubMed_21979375_A1 | Down | -0.0817702960 |
| PubMed_21979375_A2 | Down | -0.6352579433 |
| GSE35957 | Down | -0.7519312349 |
| GSE36640 | Down | -0.4707508327 |
| GSE54402 | Down | -0.2597657076 |
| GSE9593 | Down | -0.0409197820 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.0815039557 |
| GSE28863_A2 | Down | -0.0578332158 |
| GSE28863_A3 | Down | -0.1806690305 |
| GSE28863_A4 | Up | 0.0217154806 |
| GSE48662 | Up | 0.2816707628 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001478 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001478 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Microarray;Other | Functional MTI | 21199864 |
| hsa-miR-214-3p | MIMAT0000271 | MIRT024965 | Microarray;Other | Functional MTI (Weak) | 19859982 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037049 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049673 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
