HCSGD entry for LOXL1
1. General information
| Official gene symbol | LOXL1 |
|---|---|
| Entrez ID | 4016 |
| Gene full name | lysyl oxidase-like 1 |
| Other gene symbols | LOL LOXL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005507 | Copper ion binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0016641 | Oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor | IEA | molecular_function |
| GO:0018277 | Protein deamination | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0055114 | Oxidation-reduction process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9273647620 | 0.0007845978 | 0.9999902473 | 0.0524322335 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9285456923 |
| GSE13712_SHEAR | Down | -0.8101895231 |
| GSE13712_STATIC | Up | 0.0402648988 |
| GSE19018 | Up | 0.2653201908 |
| GSE19899_A1 | Down | -2.0047975601 |
| GSE19899_A2 | Down | -1.1680307879 |
| PubMed_21979375_A1 | Down | -2.5289309674 |
| PubMed_21979375_A2 | Down | -2.0825856041 |
| GSE35957 | Down | -0.1807582791 |
| GSE36640 | Down | -0.4572708575 |
| GSE54402 | Down | -1.0648335118 |
| GSE9593 | Up | 0.4484526865 |
| GSE43922 | Down | -1.1363893606 |
| GSE24585 | Down | -0.1027579877 |
| GSE37065 | Down | -0.7005506133 |
| GSE28863_A1 | Up | 0.2766974887 |
| GSE28863_A2 | Up | 0.5914221622 |
| GSE28863_A3 | Down | -0.2476346913 |
| GSE28863_A4 | Down | -0.0451063836 |
| GSE48662 | Down | -0.4700419952 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016432 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017422 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019362 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021720 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022413 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048881 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26011922 | LOX and LOXL1, 2 and 4 were localized to both amniotic and chorionic cells, whereas LOXL3 was limited to chorion |
| 24164458 | We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells |
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