HCSGD entry for LOX

1. General information

Official gene symbolLOX
Entrez ID4015
Gene full namelysyl oxidase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001568Blood vessel developmentIEAbiological_process
GO:0004720Protein-lysine 6-oxidase activityIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005581CollagenIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIEAcellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIEAbiological_process
GO:0030324Lung developmentIEAbiological_process
GO:0042060Wound healingIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0048251Elastic fiber assemblyIEAbiological_process
GO:0048545Response to steroid hormoneIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08542889710.00342331980.61386131590.1187695652

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6547791390
GSE13712_SHEARUp0.9947189725
GSE13712_STATICUp0.2273191889
GSE19018Up1.9414014579
GSE19899_A1Down-1.1453151379
GSE19899_A2Down-1.2614064171
PubMed_21979375_A1Down-1.3512817430
PubMed_21979375_A2Down-2.0370207187
GSE35957Up0.3924239805
GSE36640Up0.1584898580
GSE54402Down-1.6950841953
GSE9593Up1.9703401719
GSE43922Down-0.7914580904
GSE24585Down-0.4984757544
GSE37065Down-0.3840793710
GSE28863_A1Down-0.1798090243
GSE28863_A2Up0.1600512474
GSE28863_A3Down-0.4671354323
GSE28863_A4Down-0.2665571955
GSE48662Up0.4611839269

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018405MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26011922OBJECTIVE: Lysyl oxidase (LOX) and LOX like enzymes (LOXL1-4) physiologically remodel extracellular matrix and pathologically contribute to cellular senescence under oxidative stress (OS)
25017124Alternative promoter activation leads to the expression of a novel human lysyl oxidase variant that functions as an amine oxidase
24113189Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis
24113189We show that lysyl oxidase activity contributes to the decision to maintain senescence
24113189Indeed, in human epithelial cell the constitutive expression of the LOX or LOXL2 protein favored OIS escape, whereas inhibition of lysyl oxidase activity was found to stabilize OIS
24113189The relevance of these in vitro observations is supported by in vivo findings: in a transgenic mouse model of aggressive pancreatic ductal adenocarcinoma (PDAC), increasing lysyl oxidase activity accelerates senescence escape, whereas inhibition of lysyl oxidase activity was found to stabilize senescence, delay tumorigenesis, and increase survival
24113189Mechanistically, we show that lysyl oxidase activity favors the escape of senescence by regulating the focal-adhesion kinase
24113189Altogether, our results demonstrate that lysyl oxidase activity participates in primary tumor growth by directly impacting the senescence stability
14550642Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies
14550642Lysyl oxidase (LOX) is an extracellular copper dependent enzyme catalyzing lysine-derived cross-links in extracellular matrix proteins
11642359Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes
11642359More recently, diverse roles have been attributed to lysyl oxidase and these novel activities cover a spectrum of diverse biological functions such as developmental regulation, tumor suppression, cell motility, and cellular senescence
11642359Lysyl oxidase has also been shown to have both intracellular and intranuclear locations
9367056Lysyl oxidase, cellular senescence and tumor suppression
9367056Replicative senescence may provide a mechanism of tumor suppression and tumor suppressor genes of the extracellular matrix, like lysyl oxidase, may play a role in cellular senescence
9367056To test this hypothesis and determine whether the extracellular matrix may serve as a marker, the steady-state levels of human lysyl oxidase, alpha-I type III collagen and beta-actin transcripts were assessed in various cell lines during in vitro passage
9079631We report here a novel cDNA clone with a predicted protein sequence similar to lysyl oxidase
9079631The WS9-14 protein has a 48% identity with both lysyl oxidase and lysyl oxidase-like protein at a region corresponding to exons 2-6, implying the existence of a lysyl oxidase gene family
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