HCSGD entry for LOR
1. General information
| Official gene symbol | LOR |
|---|---|
| Entrez ID | 4014 |
| Gene full name | loricrin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001533 | Cornified envelope | IDA | cellular_component |
| GO:0005198 | Structural molecule activity | IDA | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0018149 | Peptide cross-linking | IDA | biological_process |
| GO:0030216 | Keratinocyte differentiation | IDA | biological_process |
| GO:0030674 | Protein binding, bridging | IDA | molecular_function |
| GO:0031424 | Keratinization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1819119562 | 0.8986996885 | 0.8356203490 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0650160242 |
| GSE13712_SHEAR | Down | -0.0048958690 |
| GSE13712_STATIC | Down | -0.1456275059 |
| GSE19018 | Up | 0.0660558408 |
| GSE19899_A1 | Up | 0.1218145140 |
| GSE19899_A2 | Up | 0.7355778679 |
| PubMed_21979375_A1 | Up | 0.9593365801 |
| PubMed_21979375_A2 | Up | 0.5971613288 |
| GSE35957 | Up | 0.1141291684 |
| GSE36640 | Up | 0.0356826743 |
| GSE54402 | Up | 0.2835697899 |
| GSE9593 | Down | -0.2064470898 |
| GSE43922 | Up | 0.0324224120 |
| GSE24585 | Down | -0.0585400418 |
| GSE37065 | Down | -0.0066315346 |
| GSE28863_A1 | Down | -0.0444018738 |
| GSE28863_A2 | Down | -0.1321815395 |
| GSE28863_A3 | Up | 0.1967941840 |
| GSE28863_A4 | Up | 0.1263875490 |
| GSE48662 | Up | 0.0894194446 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25840344 | Epidermal differentiation markers loricrin, filaggrin, involucrin and transglutaminase, also strongly decreased |
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