HCSGD entry for PHOX2A
1. General information
| Official gene symbol | PHOX2A |
|---|---|
| Entrez ID | 401 |
| Gene full name | paired-like homeobox 2a |
| Other gene symbols | ARIX CFEOM2 FEOM2 NCAM2 PMX2A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | molecular_function |
| GO:0003357 | Noradrenergic neuron differentiation | IC NAS | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0021523 | Somatic motor neuron differentiation | IEA | biological_process |
| GO:0021623 | Oculomotor nerve formation | IEA | biological_process |
| GO:0021642 | Trochlear nerve formation | IEA | biological_process |
| GO:0021703 | Locus ceruleus development | IEA | biological_process |
| GO:0030901 | Midbrain development | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043576 | Regulation of respiratory gaseous exchange | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IMP | biological_process |
| GO:0048485 | Sympathetic nervous system development | IEA | biological_process |
| GO:0071542 | Dopaminergic neuron differentiation | IC | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8706505984 | 0.4529539607 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1484721647 |
| GSE13712_SHEAR | Down | -0.1800691435 |
| GSE13712_STATIC | Down | -0.1149337959 |
| GSE19018 | Up | 0.1938090997 |
| GSE19899_A1 | Down | -0.0779310993 |
| GSE19899_A2 | Down | -0.2351658100 |
| PubMed_21979375_A1 | Down | -0.3131070234 |
| PubMed_21979375_A2 | Down | -0.0927841031 |
| GSE35957 | Down | -0.0617608260 |
| GSE36640 | Up | 0.0667167943 |
| GSE54402 | Down | -0.0401690852 |
| GSE9593 | Up | 0.1665990216 |
| GSE43922 | Up | 0.0586507707 |
| GSE24585 | Down | -0.0605339543 |
| GSE37065 | Down | -0.1651967577 |
| GSE28863_A1 | Down | -0.0413260504 |
| GSE28863_A2 | Down | -0.0062363290 |
| GSE28863_A3 | Up | 0.3346304122 |
| GSE28863_A4 | Up | 0.0653281969 |
| GSE48662 | Up | 0.0415667593 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023218 | Microarray | Functional MTI (Weak) | 19296470 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025054 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
