HCSGD entry for LMO2

1. General information

Official gene symbolLMO2
Entrez ID4005
Gene full nameLIM domain only 2 (rhombotin-like 1)
Other gene symbolsRBTN2 RBTNL1 RHOM2 TTG2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingIPImolecular_function
GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005667Transcription factor complexIDAcellular_component
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0042789MRNA transcription from RNA polymerase II promoterIDAbiological_process
GO:0043425BHLH transcription factor bindingIPImolecular_function
GO:0045647Negative regulation of erythrocyte differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048037Cofactor bindingIPImolecular_function
GO:0070888E-box bindingIDAmolecular_function
GO:0097067Cellular response to thyroid hormone stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07666416170.69880978310.58579991311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5310443298
GSE13712_SHEARDown-0.6913085328
GSE13712_STATICDown-0.4851698436
GSE19018Down-0.0052098335
GSE19899_A1Up0.0731608377
GSE19899_A2Up0.4482721064
PubMed_21979375_A1Up0.7261511156
PubMed_21979375_A2Up0.5605851841
GSE35957Down-0.2427867147
GSE36640Up0.1556418535
GSE54402Up1.0320110314
GSE9593Down-0.0545480346
GSE43922Up0.0462859095
GSE24585Up0.0666702653
GSE37065Up0.0158122709
GSE28863_A1Down-0.0814748324
GSE28863_A2Down-0.1164609158
GSE28863_A3Up0.2277709017
GSE28863_A4Up0.0702288123
GSE48662Up0.1829860438

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-223-3pMIMAT0000280MIRT000130Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI19278969
hsa-miR-223-3pMIMAT0000280MIRT000130Reporter assayFunctional MTI19017354
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-223-3pMIMAT00002801hsa-miR-223{Western blot}{overexpression by miRNA precursor transfection}19017354
hsa-miR-223-3pMIMAT00002801hsa-miR-223{Western blot}{overexpression}19278969
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.