HCSGD entry for LIPA
1. General information
| Official gene symbol | LIPA |
|---|---|
| Entrez ID | 3988 |
| Gene full name | lipase A, lysosomal acid, cholesterol esterase |
| Other gene symbols | CESD LAL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000902 | Cell morphogenesis | IEA | biological_process |
| GO:0001816 | Cytokine production | IEA | biological_process |
| GO:0004771 | Sterol esterase activity | IDA | molecular_function |
| GO:0005764 | Lysosome | IEA | cellular_component |
| GO:0006629 | Lipid metabolic process | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0008283 | Cell proliferation | IEA | biological_process |
| GO:0016042 | Lipid catabolic process | IEA | biological_process |
| GO:0016298 | Lipase activity | IDA | molecular_function |
| GO:0030324 | Lung development | IEA | biological_process |
| GO:0048771 | Tissue remodeling | IEA | biological_process |
| GO:0048873 | Homeostasis of number of cells within a tissue | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3036427719 | 0.1084056837 | 0.9999902473 | 0.6295997352 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3817619885 |
| GSE13712_SHEAR | Down | -0.1381671681 |
| GSE13712_STATIC | Up | 0.1415819249 |
| GSE19018 | Up | 0.8535366662 |
| GSE19899_A1 | Down | -0.9308527731 |
| GSE19899_A2 | Up | 0.0798924493 |
| PubMed_21979375_A1 | Down | -0.7196628382 |
| PubMed_21979375_A2 | Up | 0.2974172552 |
| GSE35957 | Down | -0.0190481908 |
| GSE36640 | Up | 0.3912478769 |
| GSE54402 | Down | -0.8994307288 |
| GSE9593 | Up | 0.6231067128 |
| GSE43922 | Down | -0.1487040569 |
| GSE24585 | Down | -0.1197988388 |
| GSE37065 | Up | 0.4005785779 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.2706995799 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018033 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024588 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026530 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037705 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25416716 | METHODS: We used the Center for Epidemiologic Studies Depression Scale (CES-D) and Structured Clinical Interview for DSM-IV Disorder (SCID) to assess current depressive symptoms and lifetime major depressive disorder (MDD), respectively, and telomere length was assessed from peripheral blood lymphocytes |
| 25416716 | RESULTS: Patients with depressive symptoms (CES-D >/= 16) had a 1 |
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