HCSGD entry for LIFR
1. General information
| Official gene symbol | LIFR |
|---|---|
| Entrez ID | 3977 |
| Gene full name | leukemia inhibitory factor receptor alpha |
| Other gene symbols | CD118 LIF-R SJS2 STWS SWS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004897 | Ciliary neurotrophic factor receptor activity | IDA | molecular_function |
| GO:0004923 | Leukemia inhibitory factor receptor activity | IDA | molecular_function |
| GO:0004924 | Oncostatin-M receptor activity | IDA | molecular_function |
| GO:0005127 | Ciliary neurotrophic factor receptor binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | IDA | biological_process |
| GO:0019838 | Growth factor binding | IPI | molecular_function |
| GO:0034097 | Response to cytokine | IDA | biological_process |
| GO:0038165 | Oncostatin-M-mediated signaling pathway | IDA | biological_process |
| GO:0048861 | Leukemia inhibitory factor signaling pathway | IDA | biological_process |
| GO:0070120 | Ciliary neurotrophic factor-mediated signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3815788990 | 0.0318299039 | 0.9999902473 | 0.3355205847 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2916650002 |
| GSE13712_SHEAR | Up | 0.4571021512 |
| GSE13712_STATIC | Up | 0.3609118200 |
| GSE19018 | Down | -0.6199886831 |
| GSE19899_A1 | Down | -0.2275256270 |
| GSE19899_A2 | Down | -1.3309856587 |
| PubMed_21979375_A1 | Up | 0.5523753091 |
| PubMed_21979375_A2 | Down | -0.2524144857 |
| GSE35957 | Down | -0.1436764682 |
| GSE36640 | Down | -0.6606707772 |
| GSE54402 | Down | -1.6046153290 |
| GSE9593 | Up | 0.3565929005 |
| GSE43922 | Down | -0.0095188128 |
| GSE24585 | Up | 0.1564213869 |
| GSE37065 | Up | 0.1664923151 |
| GSE28863_A1 | Up | 0.2716962752 |
| GSE28863_A2 | Up | 0.9044787354 |
| GSE28863_A3 | Down | -0.1720665281 |
| GSE28863_A4 | Down | -0.2045290402 |
| GSE48662 | Down | -0.5147182236 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017803 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT022009 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-1 | MIMAT0000416 | MIRT023796 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027384 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027645 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-27a-3p | MIMAT0000084 | MIRT028740 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030857 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036142 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
