HCSGD entry for LIF

1. General information

Official gene symbolLIF
Entrez ID3976
Gene full nameleukemia inhibitory factor
Other gene symbolsCDF DIA HILDA MLPLI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001135RNA polymerase II transcription factor recruiting transcription factor activityIDAmolecular_function
GO:0001974Blood vessel remodelingIEAbiological_process
GO:0005102Receptor bindingIPImolecular_function
GO:0005125Cytokine activityIDAmolecular_function
GO:0005146Leukemia inhibitory factor receptor bindingIDA IPImolecular_function
GO:0005615Extracellular spaceICcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007275Multicellular organismal developmentTASbiological_process
GO:0007566Embryo implantationIEAbiological_process
GO:0008083Growth factor activityIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0019827Stem cell maintenanceIEAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0033141Positive regulation of peptidyl-serine phosphorylation of STAT proteinIDAbiological_process
GO:0042503Tyrosine phosphorylation of Stat3 proteinIEAbiological_process
GO:0042511Positive regulation of tyrosine phosphorylation of Stat1 proteinIDAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIDAbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0045651Positive regulation of macrophage differentiationIDAbiological_process
GO:0045835Negative regulation of meiosisIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046697DecidualizationIEAbiological_process
GO:0046888Negative regulation of hormone secretionIDAbiological_process
GO:0048286Lung alveolus developmentIEAbiological_process
GO:0048644Muscle organ morphogenesisIEAbiological_process
GO:0048666Neuron developmentIEAbiological_process
GO:0048711Positive regulation of astrocyte differentiationIEAbiological_process
GO:0048861Leukemia inhibitory factor signaling pathwayIDAbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0060426Lung vasculature developmentIEAbiological_process
GO:0060463Lung lobe morphogenesisIEAbiological_process
GO:0060707Trophoblast giant cell differentiationIEAbiological_process
GO:0060708Spongiotrophoblast differentiationIEAbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0072108Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisIDAbiological_process
GO:0072307Regulation of metanephric nephron tubule epithelial cell differentiationIDAbiological_process
GO:1900182Positive regulation of protein localization to nucleusIDAbiological_process
GO:1901676Positive regulation of histone H3-K27 acetylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00071663310.09370479090.07730532790.5832120596

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2320666720
GSE13712_SHEARUp0.4729393991
GSE13712_STATICUp0.2086251982
GSE19018Down-3.0835684833
GSE19899_A1Up0.8267696032
GSE19899_A2Up2.2509922749
PubMed_21979375_A1Up3.8018696028
PubMed_21979375_A2Up2.1523064566
GSE35957Down-1.6318796994
GSE36640Down-1.0403452910
GSE54402Up1.1280189322
GSE9593Down-0.2936085425
GSE43922Up1.6424378420
GSE24585Up0.2796106221
GSE37065Up0.7822076921
GSE28863_A1Down-0.0769916351
GSE28863_A2Down-0.0091376819
GSE28863_A3Up0.1689679653
GSE28863_A4Up0.1329694281
GSE48662Up0.7784937568

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT001037ELISANon-Functional MTI (Weak)19011087
hsa-miR-26a-5pMIMAT0000082MIRT001039ELISANon-Functional MTI (Weak)19011087
hsa-miR-346MIMAT0000773MIRT001040ELISA//Luciferase reporter assayFunctional MTI19011087
hsa-miR-223-3pMIMAT0000280MIRT006248Luciferase reporter assay//Western blotFunctional MTI22080513
hsa-miR-199a-5pMIMAT0000231MIRT004325ELISA//Luciferase reporter assayFunctional MTI19011087
hsa-miR-125a-5pMIMAT0000443MIRT004326ELISANon-Functional MTI (Weak)19011087
hsa-miR-335-5pMIMAT0000765MIRT018057MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT029582MicroarrayFunctional MTI (Weak)19088304
hsa-miR-330-5pMIMAT0004693MIRT038243CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-346MIMAT0000773NAhsa-miR-346{ELISA}{overexpression by Synthetic miRNA Transfection}19011087
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

15880640Late MSCs also exhibited attenuated synthesis of the hematopoietic cytokines granulocyte colony-stimulating factor (G-CSF), leukemia inhibitory factor (LIF), and stem cell factor (SCF)
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