HCSGD entry for LHCGR

1. General information

Official gene symbolLHCGR
Entrez ID3973
Gene full nameluteinizing hormone/choriogonadotropin receptor
Other gene symbolsHHG LCGR LGR2 LH/CG-R LH/CGR LHR LHRHR LSH-R ULG5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001541Ovarian follicle developmentIEAbiological_process
GO:0004964Luteinizing hormone receptor activityIEAmolecular_function
GO:0005768EndosomeTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneISScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007190Activation of adenylate cyclase activityISSbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008584Male gonad developmentTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030539Male genitalia developmentTASbiological_process
GO:0032962Positive regulation of inositol trisphosphate biosynthetic processISSbiological_process
GO:0035472Choriogonadotropin hormone receptor activityISSmolecular_function
GO:0038106Choriogonadotropin hormone bindingISSmolecular_function
GO:0043950Positive regulation of cAMP-mediated signalingISSbiological_process
GO:0046544Development of secondary male sexual characteristicsIEAbiological_process
GO:0060065Uterus developmentIEAbiological_process
GO:0071371Cellular response to gonadotropin stimulusISSbiological_process
GO:0072520Seminiferous tubule developmentIEAbiological_process
GO:0090030Regulation of steroid hormone biosynthetic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60932112380.63414930280.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0744075219
GSE13712_SHEARDown-0.0144022200
GSE13712_STATICDown-0.1236036457
GSE19018Down-0.2842110035
GSE19899_A1Up0.1424263725
GSE19899_A2Up0.0159115646
PubMed_21979375_A1Up0.5093983951
PubMed_21979375_A2Up0.1186629622
GSE35957Down-0.0188522500
GSE36640Up1.2693397149
GSE54402Down-0.3249367372
GSE9593Down-0.0310502261
GSE43922Up0.0020598840
GSE24585Down-0.2195857759
GSE37065Up0.0095297132
GSE28863_A1Down-0.0322761464
GSE28863_A2Up0.0404025877
GSE28863_A3Up0.0862353123
GSE28863_A4Down-0.0283177275
GSE48662Down-0.0188619393

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GoserelinDB00014 BTD00113 | BIOD00113
MenotropinsDB00032 BTD00018 | BIOD00018
Lutropin alfaDB00044 BTD00056 | BIOD00056
CetrorelixDB00050 BTD00115 | APRD00686 | BIOD00115
Chorionic Gonadotropin (Recombinant)DB00097 BTD00034 | BIOD00034
BuserelinDB06719 -
Chorionic Gonadotropin (Human)DB09126 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-148b-3pMIMAT0000759MIRT019289MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.