HCSGD entry for LGALS3

1. General information

Official gene symbolLGALS3
Entrez ID3958
Gene full namelectin, galactoside-binding, soluble, 3
Other gene symbolsCBP35 GAL3 GALBP GALIG L31 LGALS2 MAC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005634NucleusIDA IEAcellular_component
GO:0005681Spliceosomal complexIEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005743Mitochondrial inner membraneIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006397MRNA processingIEAbiological_process
GO:0008380RNA splicingIEAbiological_process
GO:0019863IgE bindingIEAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030246Carbohydrate bindingIEAmolecular_function
GO:0031012Extracellular matrixIDAcellular_component
GO:0045087Innate immune responseTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33145093650.57372124540.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0960146659
GSE13712_SHEARDown-0.2725621666
GSE13712_STATICDown-0.1502232074
GSE19018Up0.0133598344
GSE19899_A1Up0.0197011288
GSE19899_A2Down-0.4152842459
PubMed_21979375_A1Up0.1512747121
PubMed_21979375_A2Up0.2504428038
GSE35957Down-0.1384641842
GSE36640Up0.0169503910
GSE54402Down-0.3737900220
GSE9593Up0.4931428499
GSE43922Down-0.0638667374
GSE24585Up0.1995999962
GSE37065Up0.1693033743
GSE28863_A1Up0.0895387999
GSE28863_A2Up0.3727785190
GSE28863_A3Down-0.3976156300
GSE28863_A4Up0.3010285255
GSE48662Up0.1447695372

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1669630CHEMBL45319P17931
CHEMBL1669628CHEMBL45319P17931
CHEMBL1669631CHEMBL45319P17931
CHEMBL1669631CHEMBL45319P17931
CHEMBL1253740CHEMBL45319P17931
CHEMBL1253726CHEMBL45319P17931
CHEMBL1253743CHEMBL45319P17931
CHEMBL1253843CHEMBL45319P17931
CHEMBL502001CHEMBL45319P17931
CHEMBL1669628CHEMBL45319P17931
CHEMBL1253742CHEMBL45319P17931
CHEMBL1253741CHEMBL45319P17931
CHEMBL1253745CHEMBL45319P17931
CHEMBL1253187CHEMBL45319P17931
CHEMBL1669630CHEMBL45319P17931
CHEMBL1253923CHEMBL45319P17931
CHEMBL1162115CHEMBL45319P17931
CHEMBL1254013CHEMBL45319P17931
CHEMBL52011CHEMBL45319P17931
CHEMBL1253744CHEMBL45319P17931
CHEMBL1253217CHEMBL45319P17931
CHEMBL502635CHEMBL45318P17931
CHEMBL443156CHEMBL45318P17931
CHEMBL458489CHEMBL45318P17931
CHEMBL505576CHEMBL45318P17931
CHEMBL509915CHEMBL45318P17931
CHEMBL503116CHEMBL45318P17931
CHEMBL365361CHEMBL45318P17931
CHEMBL457221CHEMBL45318P17931
CHEMBL516152CHEMBL45318P17931
CHEMBL509180CHEMBL45318P17931
CHEMBL457430CHEMBL45318P17931
CHEMBL52011CHEMBL45318P17931
CHEMBL444662CHEMBL45318P17931
CHEMBL502911CHEMBL45318P17931
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  • Drugs

Name

Drug

Accession number

2,3,5,6-Tetrafluoro-4-Methoxy-BenzamideDB01827 EXPT00667

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-424-3pMIMAT0004749MIRT003969Northern blot//qRT-PCR//Western blotFunctional MTI17889671
hsa-miR-744-5pMIMAT0004945MIRT037600CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-424-3pMIMAT00047491hsa-miR-424*{Western blot}{underexpression by 2'-O-Me antisense miRNA oligonucleotides}17889671
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26273429Senescent mesenchymal stem cells promote colorectal cancer cells growth via galectin-3 expression
26273429Analysis of the factors secreted in the MSCs culture media determined that senescent MSCs expressed and secreted high levels of galectin-3
26273429Furthermore, the simultaneous addition of recombinant galectin-3 to the co-culture systems partially restored the tumor-promoting effect of the senescent AD-MSCs
26273429Analysis of the mechanisms of senescent MSCs and galectin-3 on LoVo cells signal transduction determined that senescent MSCs and exogenous galectin-3 promoted cell growth by activating the mitogen-activated protein kinase (MAPK) (extracellular signal-regulated kinase [ERK]1/2) pathway
26273429CONCLUSIONS: Senescent MSCs may alter the tissue microenvironment and affect nearby malignant cells via cytokine secretion, and galectin-3 is an important mediator of senescent AD-MSC-mediated stimulation of colon cancer cell growth
19492299High-resolution two-dimensional electrophoresis of the MSC proteome, under conditions of in vitro self-renewal as well as osteogenic stimulation, identified several age-dependent proteins, including members of the calponin protein family as well as galectin-3
10694443In the LG1 strain of human diploid fibroblasts, galectin-3 could be found in both the nucleus and the cytoplasm of young, proliferating cells
10694443Incubation of young cells with leptomycin B, a drug that disrupts the interaction between the leucine-rich nuclear export signal and its receptor, resulted in the accumulation of galectin-3 inside the nucleus
10694443In senescent cells, galectin-3 staining remained cytoplasmic even in the presence of the drug, thus suggesting that the observed localization in the cytoplasm was due to a lack of nuclear import
10694443In heterodikaryons derived from fusion of young and senescent LG1 cells, the predominant phenotype was galectin-3 in both nuclei
10694443These results suggest that senescent LG1 cells might lack a factor(s) specifically required for galectin-3 nuclear import
9439577The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter
9439577Here we report the genomic organization of the human LGALS3 (galectin-3) gene and functional characterization of the promoter
9439577Southern blot analysis of genomic DNA revealed that galectin-3 is coded by a single gene in the human genome
9439577Because galectin-3 is an immediate-early gene whose expression is dependent on the proliferative state of the cell, this study provides the basis for determining the molecular mechanisms of transcriptional regulation in neoplasia or cellular senescence
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