HCSGD entry for LEPR
1. General information
| Official gene symbol | LEPR |
|---|---|
| Entrez ID | 3953 |
| Gene full name | leptin receptor |
| Other gene symbols | CD295 LEP-R LEPRD OB-R OBR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004896 | Cytokine receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006112 | Energy reserve metabolic process | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007275 | Multicellular organismal development | TAS | biological_process |
| GO:0008203 | Cholesterol metabolic process | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0051346 | Negative regulation of hydrolase activity | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3068356028 | 0.7988450591 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0046781741 |
| GSE13712_SHEAR | Down | -0.0231372100 |
| GSE13712_STATIC | Up | 0.0683450260 |
| GSE19018 | Up | 0.1592172401 |
| GSE19899_A1 | Up | 0.2140591594 |
| GSE19899_A2 | Up | 0.1407014570 |
| PubMed_21979375_A1 | Up | 0.1591946238 |
| PubMed_21979375_A2 | Down | -0.0543549915 |
| GSE35957 | Down | -0.0822580068 |
| GSE36640 | Up | 0.0393667477 |
| GSE54402 | Up | 0.0815210420 |
| GSE9593 | Down | -0.9695970231 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.6071154371 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017009 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037290 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18573328 | Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing biological age and distinctly marks the subpopulation of dying cells |
| 18573328 | Employing a genomic approach, we noticed that the gene encoding leptin receptor (also termed OB-R) is differentially regulated in MSC derived from aged donors as well as in MSC that had been stressed due to cultivation under hyperoxic conditions |
| 18573328 | We further observed that the leptin receptor transcript levels in primary MSC isolates are inversely correlated with the prospective number of generations that are ahead of these cells in culture, i |
| 18573328 | The MSC subpopulation, which exhibited distinctly elevated levels of leptin receptor or CD295 at the cell surface, is indistinguishable from dying cells |
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