HCSGD entry for LEP

1. General information

Official gene symbolLEP
Entrez ID3952
Gene full nameleptin
Other gene symbolsLEPD OB OBS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001542Ovulation from ovarian follicleIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001819Positive regulation of cytokine productionIEAbiological_process
GO:0001890Placenta developmentIDAbiological_process
GO:0002021Response to dietary excessIEAbiological_process
GO:0005179Hormone activityIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceISScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006111Regulation of gluconeogenesisIEAbiological_process
GO:0006112Energy reserve metabolic processIEAbiological_process
GO:0006114Glycerol biosynthetic processIEAbiological_process
GO:0007260Tyrosine phosphorylation of STAT proteinIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0008206Bile acid metabolic processIEAbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008343Adult feeding behaviorISSbiological_process
GO:0009062Fatty acid catabolic processIEAbiological_process
GO:0021954Central nervous system neuron developmentIEAbiological_process
GO:0030073Insulin secretionIEAbiological_process
GO:0030300Regulation of intestinal cholesterol absorptionIEAbiological_process
GO:0032099Negative regulation of appetiteISSbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0033197Response to vitamin EIEAbiological_process
GO:0033210Leptin-mediated signaling pathwayIEAbiological_process
GO:0033686Positive regulation of luteinizing hormone secretionIEAbiological_process
GO:0035630Bone mineralization involved in bone maturationIEAbiological_process
GO:0042445Hormone metabolic processIEAbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinIEAbiological_process
GO:0042755Eating behaviorIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043270Positive regulation of ion transportIEAbiological_process
GO:0043410Positive regulation of MAPK cascadeIEAbiological_process
GO:0045598Regulation of fat cell differentiationIEAbiological_process
GO:0045639Positive regulation of myeloid cell differentiationIEAbiological_process
GO:0045906Negative regulation of vasoconstrictionIEAbiological_process
GO:0046628Positive regulation of insulin receptor signaling pathwayIEAbiological_process
GO:0046881Positive regulation of follicle-stimulating hormone secretionIEAbiological_process
GO:0048639Positive regulation of developmental growthIDAbiological_process
GO:0050796Regulation of insulin secretionIEAbiological_process
GO:0050810Regulation of steroid biosynthetic processIEAbiological_process
GO:0050901Leukocyte tethering or rollingIEAbiological_process
GO:0051428Peptide hormone receptor bindingIEAmolecular_function
GO:0060587Regulation of lipoprotein lipid oxidationIEAbiological_process
GO:0060612Adipose tissue developmentIEAbiological_process
GO:0061037Negative regulation of cartilage developmentIEAbiological_process
GO:0070093Negative regulation of glucagon secretionIEAbiological_process
GO:0071298Cellular response to L-ascorbic acidIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:2000366Positive regulation of STAT protein import into nucleusIEAbiological_process
GO:2000486Negative regulation of glutamine transportIEAbiological_process
GO:2000491Positive regulation of hepatic stellate cell activationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04932827020.50411936480.48826498131.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6086327205
GSE13712_SHEARUp0.0135550173
GSE13712_STATICDown-0.1697874364
GSE19018Up0.1440101294
GSE19899_A1Up0.0942655187
GSE19899_A2Up0.0899521635
PubMed_21979375_A1Up0.1314521067
PubMed_21979375_A2Up0.1349992486
GSE35957Up1.8327276504
GSE36640Down-0.0552478477
GSE54402Up0.7022280310
GSE9593Down-0.0607680141
GSE43922Up0.0604239489
GSE24585Down-0.0019854343
GSE37065Up0.0500169318
GSE28863_A1Down-0.2938420910
GSE28863_A2Up0.1823835129
GSE28863_A3Up0.1838873278
GSE28863_A4Up0.0565242894
GSE48662Up1.4811136387

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 14 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27261780Formaldehyde accelerates cellular senescence in HT22 cells: possible involvement of the leptin pathway
26460847Thus, in this study, lung fibroblasts and bone osteoblasts (OBs) were used to reflect the resident stromal cells in the primary lung and bone metastatic microenvironment, respectively
26460847Lung fibroblasts (IMR90) and primary OBs were treated with 6
26460847MTT data showed that boanmycin inhibited cell proliferation in both IMR90 and OBs
26460847Moreover, senescence-associated beta-galactosidase staining showed that in response to boanmycin, there were 90% senescence cells in IMR90 and 95% in OBs
26460847Furthermore, quantitative PCR data also showed that the interleukin-6 expression was highly induced by boanmycin to six-fold in OBs
26380096Biomarkers of obesity (leptin, adiponectin), diabetes (glucose, insulin), inflammation (C-reactive protein, Interleukin-6, surface tumor necrosis factor receptor (sTNFR) I & II) and oxidative stress (F2-isoprostanes) were measured in stored blood samples
25989537Leptin and Neutrophil-Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus
25989537Blockade of leptin or NAP-2 in MSC cultures abolished SLE serum-induced senescence, while direct addition of these 2 factors could promote senescence in cultures of normal MSCs
25405871Hepatic major urinary proteins (Mup) expression, which is linked to glucose and energy metabolism, and biomarkers of metabolic health, including insulin, glucose, cholesterol, and leptin/adiponectin ratio, were likewise reduced in high-fat, dietary-restricted mice
24666525We further studied the effects of gender-influenced LDL electronegativity on aortic cellular senescence and DNA damage in leptin receptor-deficient (db/db) mice by using senescence-associated-beta-galactosidase and gammaH2AX staining, respectively
24030923Effects of leptin on endothelial function are controversial
23657974Furthermore, the expression of the adipogenic differentiation genes fatty acid binding protein-4, adiponectin, and leptin and the formation of fat droplets were impaired
21324896Mesenchymal stem cells (MSC) are multipotent cells that can be differentiated into osteoblasts (OBs), adipocytes, and chondrocytes under defined culture conditions
20591642Hormones such as leptin, ghrelin, insulin-like growth factor 1, IGFBP3, and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naive T cells in the periphery
20038483IL-7 protects both B and T lymphocytes, but IL-2, IL-10, keratinocyte growth factor, thymic stromal lymphopoietin, as well as leptin and growth hormone also have a stimulatory effect on thymopoiesis
18573328Leptin receptor/CD295 is upregulated on primary human mesenchymal stem cells of advancing biological age and distinctly marks the subpopulation of dying cells
18573328Employing a genomic approach, we noticed that the gene encoding leptin receptor (also termed OB-R) is differentially regulated in MSC derived from aged donors as well as in MSC that had been stressed due to cultivation under hyperoxic conditions
18573328We further observed that the leptin receptor transcript levels in primary MSC isolates are inversely correlated with the prospective number of generations that are ahead of these cells in culture, i
18573328The MSC subpopulation, which exhibited distinctly elevated levels of leptin receptor or CD295 at the cell surface, is indistinguishable from dying cells
17535427In undifferentiated senescent cells, PPARG2 and LPL expression is unaltered, whereas LEP and FABP4 transcript levels are increased but not in all clones
17535427Bisulfite sequencing analysis of DNA methylation reveals overall relative stability of LEP, PPARG2, FABP4 and LPL promoter CpG methylation during senescence and upon differentiation
1753542721 in the LEP promoter, whose senescence-related methylation may impair upregulation of the gene upon adipogenic stimulation
14625202Moreover, aged adipocytes show reduced gene expression for adiponectin and leptin, each of which is important in systemic regulation of energy metabolism
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