HCSGD entry for LDHB
1. General information
| Official gene symbol | LDHB |
|---|---|
| Entrez ID | 3945 |
| Gene full name | lactate dehydrogenase B |
| Other gene symbols | LDH-B LDH-H LDHBD TRG-5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004459 | L-lactate dehydrogenase activity | IEA | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006089 | Lactate metabolic process | IEA | biological_process |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | IEA | biological_process |
| GO:0019674 | NAD metabolic process | IEA | biological_process |
| GO:0019900 | Kinase binding | IEA | molecular_function |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044262 | Cellular carbohydrate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051287 | NAD binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9869920672 | 0.0359625204 | 0.9999902473 | 0.3581420734 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0795396847 |
| GSE13712_SHEAR | Down | -0.1843977675 |
| GSE13712_STATIC | Down | -0.0796858278 |
| GSE19018 | Down | -0.4397327504 |
| GSE19899_A1 | Down | -0.2123208746 |
| GSE19899_A2 | Down | -0.3144830612 |
| PubMed_21979375_A1 | Down | -0.2367853369 |
| PubMed_21979375_A2 | Down | -0.3140099687 |
| GSE35957 | Down | -0.2624428043 |
| GSE36640 | Down | -0.6268258504 |
| GSE54402 | Up | 0.2027493776 |
| GSE9593 | Down | -0.2331748007 |
| GSE43922 | Down | -0.2155206639 |
| GSE24585 | Down | -0.2750723160 |
| GSE37065 | Down | -0.3776675615 |
| GSE28863_A1 | Up | 0.1188213581 |
| GSE28863_A2 | Down | -0.0990299127 |
| GSE28863_A3 | Down | -0.1128614640 |
| GSE28863_A4 | Up | 0.1424121908 |
| GSE48662 | Down | -0.5441671267 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid | DB02401 | EXPT02463 |
| Oxamic Acid | DB03940 | EXPT02460 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019875 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-186-3p | MIMAT0004612 | MIRT038609 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039024 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040197 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043198 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045350 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046914 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-197-3p | MIMAT0000227 | MIRT048133 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048552 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050573 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
