HCSGD entry for ARHGAP5

1. General information

Official gene symbolARHGAP5
Entrez ID394
Gene full nameRho GTPase activating protein 5
Other gene symbolsGFI2 RhoGAP5 p190-B p190BRhoGAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002053Positive regulation of mesenchymal cell proliferationIEAbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0005100Rho GTPase activator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006184GTP catabolic processTASbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0008361Regulation of cell sizeIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030879Mammary gland developmentIEAbiological_process
GO:0032320Positive regulation of Ras GTPase activityTASbiological_process
GO:0032321Positive regulation of Rho GTPase activityTASbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043547Positive regulation of GTPase activityTASbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11153186050.91481472210.68960068121.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2390065068
GSE13712_SHEARUp0.2698018552
GSE13712_STATICUp0.2312918524
GSE19018Up0.4110172513
GSE19899_A1Down-0.0675872585
GSE19899_A2Down-0.0538184245
PubMed_21979375_A1Up0.3937182994
PubMed_21979375_A2Up0.2425489209
GSE35957Up0.7215535421
GSE36640Up0.5562146895
GSE54402Down-0.1656306680
GSE9593Up0.0356162748
GSE43922Up0.0006592400
GSE24585Down-0.0095602057
GSE37065Up0.1000291314
GSE28863_A1Up0.0418105169
GSE28863_A2Up0.0681246193
GSE28863_A3Down-0.0568497000
GSE28863_A4Up0.0649216391
GSE48662Up0.5967736994

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016745MicroarrayFunctional MTI (Weak)18185580
hsa-miR-128-3pMIMAT0000424MIRT021887MicroarrayFunctional MTI (Weak)17612493
hsa-miR-106a-5pMIMAT0000103MIRT048327CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050904CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.