HCSGD entry for LDHA
1. General information
| Official gene symbol | LDHA |
|---|---|
| Entrez ID | 3939 |
| Gene full name | lactate dehydrogenase A |
| Other gene symbols | GSD11 LDH1 LDHM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004459 | L-lactate dehydrogenase activity | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0005929 | Cilium | IEA | cellular_component |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0006096 | Glycolysis | NAS | biological_process |
| GO:0016616 | Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0021762 | Substantia nigra development | IEP | biological_process |
| GO:0031668 | Cellular response to extracellular stimulus | IEA | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044262 | Cellular carbohydrate metabolic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6750650317 | 0.3505052582 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2724376263 |
| GSE13712_SHEAR | Up | 0.0664709103 |
| GSE13712_STATIC | Up | 0.2303988118 |
| GSE19018 | Up | 0.4751118417 |
| GSE19899_A1 | Down | -0.0385765045 |
| GSE19899_A2 | Down | -0.0487933766 |
| PubMed_21979375_A1 | Up | 0.0439245333 |
| PubMed_21979375_A2 | Up | 0.0374070476 |
| GSE35957 | Up | 0.1007268951 |
| GSE36640 | Down | -0.5116104292 |
| GSE54402 | Up | 0.0840611237 |
| GSE9593 | Down | -0.0724570946 |
| GSE43922 | Up | 0.1269466403 |
| GSE24585 | Down | -0.6068809483 |
| GSE37065 | Up | 0.0705932936 |
| GSE28863_A1 | Down | -0.2105813739 |
| GSE28863_A2 | Up | 0.1426118491 |
| GSE28863_A3 | Down | -0.0498487109 |
| GSE28863_A4 | Up | 0.0476053554 |
| GSE48662 | Down | -0.1181631191 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Etheno-Nad | DB02483 | EXPT01343 |
| Nicotinamide | DB02701 | EXPT02307 |
| Oxamic Acid | DB03940 | EXPT02460 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025431 | Reporter assay;Proteomics | Functional MTI | 21566225 |
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028212 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320c | MIMAT0005793 | MIRT036157 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-935 | MIMAT0004978 | MIRT036678 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043068 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043554 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043959 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050430 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051827 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26121691 | Further analysis revealed that SIRT3 interacted with and deacetylated the lactate dehydrogenase A (LDHA), a key protein in regulating anaerobic glycolysis, enhancing LDHA activity |
| 24853433 | The activity of lactate dehydrogenase A, which is involved in the conversion of pyruvate to lactate, the release of lactate and the acidification of the extracellular environment, was also induced |
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