HCSGD entry for LCN2

1. General information

Official gene symbolLCN2
Entrez ID3934
Gene full namelipocalin 2
Other gene symbols24p3 MSFI NGAL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002020Protease bindingIEAmolecular_function
GO:0005215Transporter activityIEAmolecular_function
GO:0005506Iron ion bindingISSmolecular_function
GO:0005576Extracellular regionIEA ISScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006811Ion transportIEAbiological_process
GO:0009615Response to virusIEAbiological_process
GO:0009635Response to herbicideIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0015891Siderophore transportISSbiological_process
GO:0031346Positive regulation of cell projection organizationIEAbiological_process
GO:0031669Cellular response to nutrient levelsIEAbiological_process
GO:0036094Small molecule bindingIEAmolecular_function
GO:0042493Response to drugIEAbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045087Innate immune responseISSbiological_process
GO:0070207Protein homotrimerizationIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071347Cellular response to interleukin-1IEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28091195620.91807003530.97828573701.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2688881863
GSE13712_SHEARDown-0.3096676984
GSE13712_STATICUp0.0646585971
GSE19018Up0.1027700683
GSE19899_A1Up0.2561909716
GSE19899_A2Up0.1370759841
PubMed_21979375_A1Up0.1330616286
PubMed_21979375_A2Up0.1498798755
GSE35957Up0.1698619391
GSE36640Up0.0690078308
GSE54402Down-0.0866385871
GSE9593Up0.0477372746
GSE43922Up0.1417975348
GSE24585Up0.0596721891
GSE37065Up0.0435300640
GSE28863_A1Down-0.1123054968
GSE28863_A2Down-0.0813374668
GSE28863_A3Up0.2273711824
GSE28863_A4Up0.1588683403
GSE48662Down-0.0425244706

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Methyl Nonanoate (Ester)DB01631 EXPT02376
2,3-Dihydroxy-Benzoic AcidDB01672 EXPT01121
Carboxymycobactin SDB01926 EXPT00951
2,3,-DihydroxybenzoylserineDB02710 EXPT01126
Carboxymycobactin TDB04043 EXPT00952
Trencam-3,2-HopoDB04476 EXPT01118

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24452457Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress
24452457Lipocalin 2 (Lcn2) has been the subject of intensive research, due to its contribution to many physiological and pathophysiological conditions
24452457The implication of Lcn2 has been reported in many conditions where senescence also occurs
24452457In the present study, we evaluated the role of Lcn2 in the occurrence of senescence in human bone marrow-derived mesenchymal stem cells (hB-MSCs) under oxidative conditions
24452457When hB-MSCs were genetically engineered to over-express Lcn2 (MSC-Lcn2) and exposed to H2O2, the proliferation rate of the cells increased
24452457Our results revealed that over-expression of recombinant Lcn2 in hB-MSCs decreases senescence induced by H2O2 treatment
24452457Senescent cells were observed in aged hB-MSCs; however, no alteration in the expression level of Lcn2 was detected compared to earlier passages
24452457Finally, a higher amount of Lcn2 protein was detected in the plasma of the elderly than in young people
24452457Our findings suggest that Lcn2 might restore the health and regeneration potential of MSCs by decreasing senescence
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