HCSGD entry for LCAT

1. General information

Official gene symbolLCAT
Entrez ID3931
Gene full namelecithin-cholesterol acyltransferase
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004607Phosphatidylcholine-sterol O-acyltransferase activityIDA IEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0006629Lipid metabolic processIEAbiological_process
GO:0006644Phospholipid metabolic processIDAbiological_process
GO:0006656Phosphatidylcholine biosynthetic processIDAbiological_process
GO:0008203Cholesterol metabolic processIDAbiological_process
GO:0008374O-acyltransferase activityIEAmolecular_function
GO:0030301Cholesterol transportIDAbiological_process
GO:0034186Apolipoprotein A-I bindingIPImolecular_function
GO:0034364High-density lipoprotein particleIDAcellular_component
GO:0034372Very-low-density lipoprotein particle remodelingIDAbiological_process
GO:0034375High-density lipoprotein particle remodelingIDAbiological_process
GO:0034435Cholesterol esterificationIDAbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042158Lipoprotein biosynthetic processIEAbiological_process
GO:0042632Cholesterol homeostasisIDAbiological_process
GO:0043691Reverse cholesterol transportIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0090107Regulation of high-density lipoprotein particle assemblyIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.17152467230.30852579690.81375286591.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1469970050
GSE13712_SHEARUp0.2765652058
GSE13712_STATICUp0.1558599285
GSE19018Up0.0386439179
GSE19899_A1Down-0.1190306166
GSE19899_A2Up0.0621140231
PubMed_21979375_A1Down-0.0157852912
PubMed_21979375_A2Up0.4429185443
GSE35957Down-0.3077105424
GSE36640Up0.1593703688
GSE54402Down-0.3952016307
GSE9593Down-0.2182573085
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.2659037046
GSE28863_A2Down-0.3319095514
GSE28863_A3Up1.1064662604
GSE28863_A4Up0.3714686960
GSE48662Up0.3060150558

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029711MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

1251568The lecithin:cholesterol acyltransferase (LCAT) activity and lysolecithin content of human blood stored under standard blood transfusion service conditions at 4 degrees C for 6 weeks has been investigated
1251568Cooling the blood to 4 degrees C rapidly inactivates the LCAT reaction, but the enzyme is not denatured during storage under these conditions
1251568Citrate in the anticoagulant did not activate the LCAT reaction in freshly-taken whole blood
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