HCSGD entry for ARHGAP4

1. General information

Official gene symbolARHGAP4
Entrez ID393
Gene full nameRho GTPase activating protein 4
Other gene symbolsC1 RGC1 RhoGAP4 SrGAP4 p115
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005100Rho GTPase activator activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0007010Cytoskeleton organizationTASbiological_process
GO:0007165Signal transductionIEAbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007266Rho protein signal transductionTASbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0010764Negative regulation of fibroblast migrationIEAbiological_process
GO:0030426Growth coneIEAcellular_component
GO:0030517Negative regulation of axon extensionIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16375562100.79789405420.80100570531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1421474552
GSE13712_SHEARUp0.5921729751
GSE13712_STATICUp0.3385524762
GSE19018Up0.1987739373
GSE19899_A1Up0.0192839706
GSE19899_A2Up0.0347161522
PubMed_21979375_A1Up0.2848571159
PubMed_21979375_A2Down-0.0500957067
GSE35957Down-0.0033003109
GSE36640Up0.0746482492
GSE54402Up0.1807951632
GSE9593Up0.0937981486
GSE43922Up0.0481301650
GSE24585Down-0.0709020368
GSE37065Up0.0282637567
GSE28863_A1Down-0.1819747092
GSE28863_A2Down-0.1275777578
GSE28863_A3Up0.3228148151
GSE28863_A4Up0.1459782119
GSE48662Up0.1953280324

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.