HCSGD entry for LASP1
1. General information
| Official gene symbol | LASP1 |
|---|---|
| Entrez ID | 3927 |
| Gene full name | LIM and SH3 protein 1 |
| Other gene symbols | Lasp-1 MLN50 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005070 | SH3/SH2 adaptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0006811 | Ion transport | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009967 | Positive regulation of signal transduction | TAS | biological_process |
| GO:0015075 | Ion transmembrane transporter activity | IEA ISS | molecular_function |
| GO:0030864 | Cortical actin cytoskeleton | IEA ISS | cellular_component |
| GO:0051015 | Actin filament binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9675651039 | 0.0615138863 | 0.9999902473 | 0.4672747475 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3831206728 |
| GSE13712_SHEAR | Up | 0.1552132983 |
| GSE13712_STATIC | Up | 0.1112684224 |
| GSE19018 | Down | -0.0114939813 |
| GSE19899_A1 | Down | -0.5524899473 |
| GSE19899_A2 | Down | -0.3148128256 |
| PubMed_21979375_A1 | Down | -0.5328082648 |
| PubMed_21979375_A2 | Down | -0.1229344103 |
| GSE35957 | Up | 0.0654263117 |
| GSE36640 | Down | -0.0098264100 |
| GSE54402 | Down | -0.2909533334 |
| GSE9593 | Down | -0.0030906255 |
| GSE43922 | Down | -0.1458201846 |
| GSE24585 | Up | 0.2258818787 |
| GSE37065 | Down | -0.2750869656 |
| GSE28863_A1 | Down | -0.1108953095 |
| GSE28863_A2 | Down | -0.1169303980 |
| GSE28863_A3 | Down | -0.2056682988 |
| GSE28863_A4 | Down | -0.0291949813 |
| GSE48662 | Down | -0.2226955350 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT002808 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT002808 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 20843712 |
| hsa-miR-1 | MIMAT0000416 | MIRT002808 | Immunoblot//Immunofluorescence//Immunoprecipitaion//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 22210864 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT003708 | qRT-PCR//Microarray | Functional MTI (Weak) | 19168627 |
| hsa-miR-218-5p | MIMAT0000275 | MIRT003708 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 20843712 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT005813 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay | Functional MTI | 20843712 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016319 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-505-5p | MIMAT0004776 | MIRT037933 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046268 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
