HCSGD entry for STMN1
1. General information
| Official gene symbol | STMN1 |
|---|---|
| Entrez ID | 3925 |
| Gene full name | stathmin 1 |
| Other gene symbols | C1orf215 LAP18 Lag OP18 PP17 PP19 PR22 SMN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0007019 | Microtubule depolymerization | IDA | biological_process |
| GO:0007052 | Mitotic spindle organization | IDA | biological_process |
| GO:0007165 | Signal transduction | NAS | biological_process |
| GO:0007409 | Axonogenesis | IEA | biological_process |
| GO:0009615 | Response to virus | IEP | biological_process |
| GO:0015631 | Tubulin binding | IDA | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0031115 | Negative regulation of microtubule polymerization | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0051272 | Positive regulation of cellular component movement | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9935535428 | 0.0016147373 | 0.9999902473 | 0.0775391621 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1922849995 |
| GSE13712_SHEAR | Down | -0.4656267139 |
| GSE13712_STATIC | Down | -0.2615874212 |
| GSE19018 | Up | 0.2946045916 |
| GSE19899_A1 | Down | -0.5570102047 |
| GSE19899_A2 | Down | -0.9912844286 |
| PubMed_21979375_A1 | Down | -0.8650996461 |
| PubMed_21979375_A2 | Down | -1.4190873212 |
| GSE35957 | Down | -0.8255785093 |
| GSE36640 | Down | -1.5027530107 |
| GSE54402 | Down | -0.6331698280 |
| GSE9593 | Down | -0.9922156449 |
| GSE43922 | Down | -0.7775252122 |
| GSE24585 | Up | 0.2143788880 |
| GSE37065 | Down | -0.5109836501 |
| GSE28863_A1 | Down | -0.4267253350 |
| GSE28863_A2 | Up | 0.4260273611 |
| GSE28863_A3 | Down | -0.0688206020 |
| GSE28863_A4 | Down | -0.1154015385 |
| GSE48662 | Down | -0.7165687097 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-223-3p | MIMAT0000280 | MIRT000129 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18555017 |
| hsa-miR-223-3p | MIMAT0000280 | MIRT000129 | Flow//Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22470493 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT006149 | Luciferase reporter assay | Functional MTI | 23071542 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016339 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021403 | Reporter assay;Western blot;qRT-PCR | Functional MTI | 20362537 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021744 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037496 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042177 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-223-3p | MIMAT0000280 | 1 | hsa-miR-223 | 18555017 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23185405 | METHODOLOGY: To address this issue we have measured in the blood leucocytes of MDD patients (N=17) and controls (N=16) the expression of two genes identified as robust biomarkers of human aging and telomere dysfunction: p16(INK4a) and STMN1 |
| 23185405 | RESULTS: The OGG1, p16(INK4a), and STMN1 gene were significantly up-regulated (25 to 100%) in the leucocytes of MDD patients |
| 23185405 | Expression of p16(INK4a) and STMN1 was directly correlated with anxiety scores in the depression group, and that of p16(INK4a), STMN and TERT with the depression and anxiety scores in the combined sample (MDD plus controls) |
| 23185405 | CONCLUSIONS: Expression of p16(INK4) and STMN1 is a promising biomarker for future epidemiological assessment of the somatic impact of depressive and anxious symptoms, at both clinical and subclinical level in both depressive patients and general population |
| 20160501 | GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells |
| 20160501 | Op18/stathmin is an oncoprotein that regulates microtubule stabilization |
| 20160501 | Both survivin and Op18 have been proposed as therapeutic targets for cancer |
| 20160501 | However, few small molecule inhibitors of survivin and Op18 have been reported |
| 20160501 | In this study, we have identified a novel small molecule compound (GDP366) which potently and selectively inhibited the expression of both survivin and Op18 |
| 20160501 | It decreased both the mRNA and protein levels of survivin and Op18 |
| 20160501 | We conclude that GDP366 is a novel dual inhibitor of survivin and Op18 |
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