HCSGD entry for LAMP2
1. General information
| Official gene symbol | LAMP2 |
|---|---|
| Entrez ID | 3920 |
| Gene full name | lysosomal-associated membrane protein 2 |
| Other gene symbols | CD107b LAMP-2 LAMPB LGP110 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016020 | Membrane | IDA IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030670 | Phagocytic vesicle membrane | IEA | cellular_component |
| GO:0031088 | Platelet dense granule membrane | IDA TAS | cellular_component |
| GO:0031902 | Late endosome membrane | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1543016375 | 0.5057607576 | 0.7816621824 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1298462048 |
| GSE13712_SHEAR | Down | -0.1027544163 |
| GSE13712_STATIC | Up | 0.1100184766 |
| GSE19018 | Up | 0.7178167306 |
| GSE19899_A1 | Down | -0.0122756943 |
| GSE19899_A2 | Up | 0.0008260077 |
| PubMed_21979375_A1 | Down | -0.1385306385 |
| PubMed_21979375_A2 | Down | -0.1830204701 |
| GSE35957 | Up | 0.2996941256 |
| GSE36640 | Up | 0.9742480280 |
| GSE54402 | Down | -0.5661058611 |
| GSE9593 | Up | 0.8687824184 |
| GSE43922 | Down | -0.1960512086 |
| GSE24585 | Down | -0.0639501819 |
| GSE37065 | Up | 0.1615597911 |
| GSE28863_A1 | Up | 0.1242700672 |
| GSE28863_A2 | Up | 0.3281939842 |
| GSE28863_A3 | Down | -0.4626993391 |
| GSE28863_A4 | Up | 0.0469180082 |
| GSE48662 | Down | -0.1815639394 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022427 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027054 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030821 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031571 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21858089 | METHODOLOGY/PRINCIPAL FINDINGS: Depletion of ATG7, ATG12, or lysosomal-associated membrane protein 2 (Lamp2) by transfecting siRNA or infecting cells with a virus containing gene-specific shRNA resulted in a senescence-like state in two strains of primary human fibroblasts |
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