HCSGD entry for LAMP1
1. General information
| Official gene symbol | LAMP1 |
|---|---|
| Entrez ID | 3916 |
| Gene full name | lysosomal-associated membrane protein 1 |
| Other gene symbols | CD107a LAMPA LGP120 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005771 | Multivesicular body | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006914 | Autophagy | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0010008 | Endosome membrane | IEA | cellular_component |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0042470 | Melanosome | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0044194 | Cytolytic granule | IEA | cellular_component |
| GO:0048102 | Autophagic cell death | IEA | biological_process |
| GO:0097208 | Alveolar lamellar body | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1635991794 | 0.8236831047 | 0.8008502975 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1924818695 |
| GSE13712_SHEAR | Up | 0.0152850898 |
| GSE13712_STATIC | Up | 0.0560763584 |
| GSE19018 | Up | 0.3306408873 |
| GSE19899_A1 | Down | -0.1017194855 |
| GSE19899_A2 | Up | 0.2863919606 |
| PubMed_21979375_A1 | Down | -0.1940340428 |
| PubMed_21979375_A2 | Down | -0.5757108969 |
| GSE35957 | Down | -0.2508347311 |
| GSE36640 | Up | 0.3578413822 |
| GSE54402 | Down | -0.3055626044 |
| GSE9593 | Up | 0.7426660925 |
| GSE43922 | Up | 0.0021085642 |
| GSE24585 | Up | 0.0419105876 |
| GSE37065 | Up | 0.0348540290 |
| GSE28863_A1 | Up | 0.5595477699 |
| GSE28863_A2 | Up | 0.5064817126 |
| GSE28863_A3 | Up | 0.0987299889 |
| GSE28863_A4 | Up | 0.1060732343 |
| GSE48662 | Up | 0.0038688068 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-378a-3p | MIMAT0000732 | MIRT019659 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT019659 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023236 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1227-3p | MIMAT0005580 | MIRT036408 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039887 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041727 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27853638 | Remarkably, NK cell population was not affected by the melphalan dose used, but rather displayed activation features as indicated by CD107a and CD69 expression |
| 20212459 | The expression of LC3 was closely related to the expression of cathepsin D, LAMP-1, and senescent markers |
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