HCSGD entry for LAMB1
1. General information
| Official gene symbol | LAMB1 |
|---|---|
| Entrez ID | 3912 |
| Gene full name | laminin, beta 1 |
| Other gene symbols | CLM LIS5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005198 | Structural molecule activity | NAS | molecular_function |
| GO:0005201 | Extracellular matrix structural constituent | IDA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005604 | Basement membrane | IDA TAS | cellular_component |
| GO:0005606 | Laminin-1 complex | IDA IEA IPI TAS | cellular_component |
| GO:0005607 | Laminin-2 complex | IDA TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007162 | Negative regulation of cell adhesion | IEA | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0019899 | Enzyme binding | IEA | molecular_function |
| GO:0021812 | Neuronal-glial interaction involved in cerebral cortex radial glia guided migration | IMP | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0031012 | Extracellular matrix | ISS | cellular_component |
| GO:0031175 | Neuron projection development | IDA IEA | biological_process |
| GO:0034446 | Substrate adhesion-dependent cell spreading | IDA | biological_process |
| GO:0042476 | Odontogenesis | IDA | biological_process |
| GO:0043208 | Glycosphingolipid binding | IEA | molecular_function |
| GO:0043257 | Laminin-8 complex | IDA TAS | cellular_component |
| GO:0043259 | Laminin-10 complex | IDA IEA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA ISS | cellular_component |
| GO:0050679 | Positive regulation of epithelial cell proliferation | TAS | biological_process |
| GO:0070062 | Extracellular vesicular exosome | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1131453364 | 0.0630854945 | 0.6924199953 | 0.4736866515 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2170837684 |
| GSE13712_SHEAR | Down | -0.0027232405 |
| GSE13712_STATIC | Up | 0.1554342857 |
| GSE19018 | Down | -0.3360314967 |
| GSE19899_A1 | Up | 0.5666921550 |
| GSE19899_A2 | Down | -0.4504709888 |
| PubMed_21979375_A1 | Down | -0.0578664830 |
| PubMed_21979375_A2 | Up | 0.6817321201 |
| GSE35957 | Down | -1.5749114572 |
| GSE36640 | Up | 0.8022182309 |
| GSE54402 | Down | -0.4708877423 |
| GSE9593 | Down | -0.1463313597 |
| GSE43922 | Up | 0.2668223091 |
| GSE24585 | Up | 0.0479824560 |
| GSE37065 | Down | -0.5149446759 |
| GSE28863_A1 | Up | 0.8554211504 |
| GSE28863_A2 | Up | 0.6728780396 |
| GSE28863_A3 | Down | -0.6069360504 |
| GSE28863_A4 | Down | -0.3632973355 |
| GSE48662 | Down | -0.4082794514 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT019028 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032050 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-760 | MIMAT0004957 | MIRT036727 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-500a-3p | MIMAT0002871 | MIRT041153 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041314 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045771 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
