HCSGD entry for HES5

1. General information

Official gene symbolHES5
Entrez ID388585
Gene full namehairy and enhancer of split 5 (Drosophila)
Other gene symbolsbHLHb38
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionISSmolecular_function
GO:0002062Chondrocyte differentiationISSbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0006461Protein complex assemblyISSbiological_process
GO:0007155Cell adhesionISSbiological_process
GO:0007219Notch signaling pathwayIMP TASbiological_process
GO:0007224Smoothened signaling pathwayISSbiological_process
GO:0007420Brain developmentISSbiological_process
GO:0008134Transcription factor bindingNASmolecular_function
GO:0008284Positive regulation of cell proliferationIMPbiological_process
GO:0014003Oligodendrocyte developmentISSbiological_process
GO:0021537Telencephalon developmentISSbiological_process
GO:0021781Glial cell fate commitmentISSbiological_process
GO:0021861Forebrain radial glial cell differentiationIEAbiological_process
GO:0021915Neural tube developmentISSbiological_process
GO:0022010Central nervous system myelinationISSbiological_process
GO:0030513Positive regulation of BMP signaling pathwayISSbiological_process
GO:0031641Regulation of myelinationISSbiological_process
GO:0042491Auditory receptor cell differentiationISSbiological_process
GO:0042517Positive regulation of tyrosine phosphorylation of Stat3 proteinISSbiological_process
GO:0042668Auditory receptor cell fate determinationIEAbiological_process
GO:0043010Camera-type eye developmentISSbiological_process
GO:0045595Regulation of cell differentiationISSbiological_process
GO:0045665Negative regulation of neuron differentiationISSbiological_process
GO:0045747Positive regulation of Notch signaling pathwayIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048469Cell maturationISSbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIGIbiological_process
GO:0048708Astrocyte differentiationISSbiological_process
GO:0048712Negative regulation of astrocyte differentiationISSbiological_process
GO:0048715Negative regulation of oligodendrocyte differentiationISSbiological_process
GO:0050767Regulation of neurogenesisISSbiological_process
GO:0051216Cartilage developmentIDAbiological_process
GO:0072049Comma-shaped body morphogenesisIEAbiological_process
GO:0072050S-shaped body morphogenesisIEAbiological_process
GO:0072086Specification of loop of Henle identityIEAbiological_process
GO:0072282Metanephric nephron tubule morphogenesisIEAbiological_process
GO:0097150Neuronal stem cell maintenanceIEPbiological_process
GO:2000737Negative regulation of stem cell differentiationIMPbiological_process
GO:2000974Negative regulation of pro-B cell differentiationISSbiological_process
GO:2000978Negative regulation of forebrain neuron differentiationIEAbiological_process
GO:2000981Negative regulation of inner ear receptor cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41124909390.76885402910.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1767190881
GSE13712_SHEARUp0.0313650893
GSE13712_STATICDown-0.0468175507
GSE19018Up0.0844338203
GSE19899_A1Up0.1817528702
GSE19899_A2Up0.2319579164
PubMed_21979375_A1Down-0.2083108656
PubMed_21979375_A2Down-0.2470577734
GSE35957Up0.3162787702
GSE36640Down-0.1443511205
GSE54402Down-0.0023194426
GSE9593Up0.1199363237
GSE43922Up0.1856017842
GSE24585Up0.0310320706
GSE37065Up0.0117238810
GSE28863_A1Down-0.1323747755
GSE28863_A2Up0.1044286114
GSE28863_A3Up0.3919452036
GSE28863_A4Up0.0275757745
GSE48662Down-0.1350192242

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.