HCSGD entry for KRT18
1. General information
| Official gene symbol | KRT18 |
|---|---|
| Entrez ID | 3875 |
| Gene full name | keratin 18 |
| Other gene symbols | CYK18 K18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IDA | cellular_component |
| GO:0005882 | Intermediate filament | IDA IEA | cellular_component |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0009653 | Anatomical structure morphogenesis | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0033209 | Tumor necrosis factor-mediated signaling pathway | IEA | biological_process |
| GO:0034451 | Centriolar satellite | IDA | cellular_component |
| GO:0043000 | Golgi to plasma membrane CFTR protein transport | IDA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IDA | biological_process |
| GO:0045095 | Keratin filament | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0097110 | Scaffold protein binding | IPI | molecular_function |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IEA | biological_process |
| GO:0097284 | Hepatocyte apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1547667452 | 0.0422136165 | 0.7822116123 | 0.3864711652 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.5769446631 |
| GSE13712_SHEAR | Up | 0.2354456261 |
| GSE13712_STATIC | Up | 0.5447208428 |
| GSE19018 | Down | -0.3646984818 |
| GSE19899_A1 | Down | -0.3395739298 |
| GSE19899_A2 | Up | 0.1293098494 |
| PubMed_21979375_A1 | Up | 0.4940538433 |
| PubMed_21979375_A2 | Down | -0.1395027757 |
| GSE35957 | Up | 1.5787639815 |
| GSE36640 | Down | -0.5326989732 |
| GSE54402 | Up | 0.1084788348 |
| GSE9593 | Down | -0.0925718898 |
| GSE43922 | Down | -0.2962133533 |
| GSE24585 | Up | 0.2583259221 |
| GSE37065 | Down | -0.3463311134 |
| GSE28863_A1 | Down | -0.1220518714 |
| GSE28863_A2 | Down | -0.2272768578 |
| GSE28863_A3 | Up | 0.1795289302 |
| GSE28863_A4 | Up | 0.1453067411 |
| GSE48662 | Down | -0.4195469739 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023274 | Proteomics | Functional MTI (Weak) | 17612493 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029677 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27043296 | At pericentric heterochromatin, SIRT6 promotes deacetylation of a new substrate, residue K18 of histone H3 (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts |
| 23019197 | However, the ratios of cystic fibrosis transmembrane conductance regulator (CFTR) and solute-linked carrier 26 gene family (Slc26a6) mRNA expression in relation to cytokeratin-18 were not altered in duodenal mucosa |
| 14580871 | In contrast, in vitro-differentiated neuroendocrine-like cells from prostate organoide cultures, expressing chromogranin A and cytokeratin 18, strongly stained positive for SA-beta-gal |
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