HCSGD entry for RHOA
1. General information
| Official gene symbol | RHOA |
|---|---|
| Entrez ID | 387 |
| Gene full name | ras homolog family member A |
| Other gene symbols | ARH12 ARHA RHO12 RHOH12 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005938 | Cell cortex | IDA | cellular_component |
| GO:0006184 | GTP catabolic process | TAS | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA TAS | biological_process |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008152 | Metabolic process | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0017022 | Myosin binding | IPI | molecular_function |
| GO:0030027 | Lamellipodium | ISS | cellular_component |
| GO:0030036 | Actin cytoskeleton organization | TAS | biological_process |
| GO:0030054 | Cell junction | TAS | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030334 | Regulation of cell migration | IMP | biological_process |
| GO:0030496 | Midbody | IEA | cellular_component |
| GO:0032154 | Cleavage furrow | IEA | cellular_component |
| GO:0032467 | Positive regulation of cytokinesis | IMP | biological_process |
| GO:0033688 | Regulation of osteoblast proliferation | ISS | biological_process |
| GO:0036089 | Cleavage furrow formation | IDA | biological_process |
| GO:0042346 | Positive regulation of NF-kappaB import into nucleus | NAS | biological_process |
| GO:0043123 | Positive regulation of I-kappaB kinase/NF-kappaB signaling | IEP | biological_process |
| GO:0043296 | Apical junction complex | IDA | cellular_component |
| GO:0043297 | Apical junction assembly | IMP | biological_process |
| GO:0043931 | Ossification involved in bone maturation | ISS | biological_process |
| GO:0045666 | Positive regulation of neuron differentiation | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0050770 | Regulation of axonogenesis | TAS | biological_process |
| GO:0050771 | Negative regulation of axonogenesis | TAS | biological_process |
| GO:0050772 | Positive regulation of axonogenesis | TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051496 | Positive regulation of stress fiber assembly | IDA | biological_process |
| GO:0061383 | Trabecula morphogenesis | ISS | biological_process |
| GO:0090307 | Spindle assembly involved in mitosis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9478169712 | 0.2065735192 | 0.9999902473 | 0.8813953206 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0008482379 |
| GSE13712_SHEAR | Up | 0.0167717706 |
| GSE13712_STATIC | Down | -0.0861842223 |
| GSE19018 | Up | 0.2755310231 |
| GSE19899_A1 | Down | -0.2309398318 |
| GSE19899_A2 | Down | -0.1697120427 |
| PubMed_21979375_A1 | Down | -0.0329233953 |
| PubMed_21979375_A2 | Down | -0.4433746751 |
| GSE35957 | Up | 0.0827802631 |
| GSE36640 | Up | 0.0100960296 |
| GSE54402 | Down | -0.0061818421 |
| GSE9593 | Up | 0.1590074233 |
| GSE43922 | Up | 0.0106249011 |
| GSE24585 | Up | 0.0718611980 |
| GSE37065 | Down | -0.1483106129 |
| GSE28863_A1 | Down | -0.1837318374 |
| GSE28863_A2 | Down | -0.3625707585 |
| GSE28863_A3 | Down | -0.0480812758 |
| GSE28863_A4 | Down | -0.0431165575 |
| GSE48662 | Down | -0.4023049734 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT000088 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19524507 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT000088 | qRT-PCR//Western blot | Functional MTI | 22854067 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT000717 | Luciferase reporter assay | Functional MTI | 19617899 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT000717 | Luciferase reporter assay// | Functional MTI | 19935707 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001961 | Luciferase reporter assay | Functional MTI | 18794355 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT004036 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21186079 |
| hsa-miR-31-3p | MIMAT0004504 | MIRT007065 | qRT-PCR//Western blot | Functional MTI | 22854067 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT007345 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23272142 |
| hsa-miR-375 | MIMAT0000728 | MIRT019977 | Western blot;qRT-PCR;Microarray | Functional MTI | 20584986 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022883 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-320c | MIMAT0005793 | MIRT036175 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-146b-5p | MIMAT0002809 | MIRT041611 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046885 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | 2 | hsa-miR-155 | {immunoblotting} | {overexpression by miRNA precursor transfection} | 18794355 | |
| hsa-miR-155-5p | MIMAT0000646 | 3 | hsa-miR-155 | {immunoblotting} | {overexpression by miRNA precursor transfection} | 18794355 | |
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | {immunoblotting} | {overexpression by miRNA precursor transfection} | 18794355 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26649141 | Modulation of RhoA GTPase Activity Sensitizes Human Cervix Carcinoma Cells to gamma-Radiation by Attenuating DNA Repair Pathways |
| 26649141 | Although RhoA GTPase overexpression/hyperactivation is observed in many malignancies, the effect of RhoA activity modulation on cancer radiosensitivity has not been previously investigated |
| 26649141 | In agreement with these results, RhoA inhibition by C3 toxin expression drastically affected homologous recombination (HR) and nonhomologous end joining (NHEJ) |
| 26649141 | These data suggest that modulation of RhoA GTPase activity impairs DNA damage repair, increasing HeLa cell radiosensitivity |
| 17658517 | Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity |
| 17658517 | In this study, we showed that RhoA activation modulated phosphatase during senescence-like arrest in human prostate cancer cells |
| 17658517 | Thus, we postulate that RhoA signaling may protect cells against cellular senescence by maintaining phosphatase activity and Erk dephosphorylation |
| 16316623 | Lovastatin-induced RhoA modulation and its effect on senescence in prostate cancer cells |
| 16316623 | We found that constitutively active RhoA (caRhoA) reversed lovastatin-induced senescence in caRhoA-transfected PC-3 cells |
| 16316623 | Thus, we postulate that modulation of RhoA may be critical in lovastatin-induced senescence in PC-3 cells |
| 11795508 | Perinuclear expression of Rac1 was prominent in the HDF cells and V12C40 expresser; however, in the V12S35 expresser, translocation of Rac1 from perinucleus to nucleus and strong expression of RhoA were obvious |
| 11795508 | In summary, the H-ras double mutant expressers induced premature senescence through the MEK pathway, accompanied by nuclear accumulation of actin and Rac1 proteins, cytoplasmic retention of p-Erk1/2, and marked induction of RhoA expression, suggesting the translocational inefficiency of the intracellular proteins in the senescent HDF cells |
| 11080532 | Perinuclear expression of Racl was prominent in the HDF cells and V12C40 expresser, while translocation of Racl from perinucleus to nucleus and strong expression of RhoA were observed in the V12S35 expresser |
| 11080532 | In summary, the induced premature senescence by H-ras double mutants were accompanied by nuclear accumulation of actin and Racl proteins, cytoplasmic retention of p-Erk1/2 and marked induction of RhoA expression mainly through dysregulation of the MEK pathway |
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