HCSGD entry for KRT14
1. General information
| Official gene symbol | KRT14 |
|---|---|
| Entrez ID | 3861 |
| Gene full name | keratin 14 |
| Other gene symbols | CK14 EBS3 EBS4 K14 NFJ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005200 | Structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005882 | Intermediate filament | IDA | cellular_component |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0010043 | Response to zinc ion | IEA | biological_process |
| GO:0010212 | Response to ionizing radiation | IEA | biological_process |
| GO:0030855 | Epithelial cell differentiation | IEA | biological_process |
| GO:0031581 | Hemidesmosome assembly | TAS | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0045095 | Keratin filament | IDA | cellular_component |
| GO:0045110 | Intermediate filament bundle assembly | IMP | biological_process |
| GO:0071944 | Cell periphery | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1464313476 | 0.3313499563 | 0.7667120700 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0348323104 |
| GSE13712_SHEAR | Up | 0.0126779568 |
| GSE13712_STATIC | Up | 0.0438207836 |
| GSE19018 | Down | -0.0860587391 |
| GSE19899_A1 | Up | 0.0910286110 |
| GSE19899_A2 | Down | 0.0000000000 |
| PubMed_21979375_A1 | Down | -0.2411975505 |
| PubMed_21979375_A2 | Up | 0.0415820781 |
| GSE35957 | Up | 2.3424114784 |
| GSE36640 | Down | -0.0457015749 |
| GSE54402 | Down | -0.0519712324 |
| GSE9593 | Down | -0.1764884984 |
| GSE43922 | Up | 0.2145092215 |
| GSE24585 | Up | 0.0755052511 |
| GSE37065 | Down | -0.1792408293 |
| GSE28863_A1 | Down | -0.3356712976 |
| GSE28863_A2 | Up | 0.0906280169 |
| GSE28863_A3 | Up | 0.4019401246 |
| GSE28863_A4 | Up | 0.0457866179 |
| GSE48662 | Down | -0.0123104924 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023065 | Proteomics;Microarray | Non-Functional MTI (Weak) | 18668037 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023354 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21694780 | Notably, the altered expression of these genes were closely associated with epigenetic dysregulation of histone H3 acetylation in K9 and K14, but not with methylation of CpG islands in the promoter regions of most of these genes |
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